CD42b/GP1BA Protein, Human (515a.a, HEK293, His)

CD42b/GP1BA protein is an important platelet membrane protein that interacts with the A1 domain of von Willebrand factor and contributes to the formation of subendothelial platelet plugs. Its GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively called GP-Ib. CD42b/GP1BA Protein, Human (515a.a, HEK293, His) is the recombinant human-derived CD42b/GP1BA protein, expressed by HEK293 , with C-His labeled tag. The total length of CD42b/GP1BA Protein, Human (515a.a, HEK293, His) is 515 a.a., with molecular weight of 100-130 kDa.

CD42b/GP1BA, a crucial surface membrane protein on platelets, plays a pivotal role in the formation of platelet plugs by engaging with the A1 domain of von Willebrand factor (vWF), which is already bound to the subendothelium. The GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively known as GP-Ib. The GP-IX subunit is intricately associated with the GP-Ib heterodimer through a non-covalent linkage. Notably, CD42b/GP1BA interacts with filamin B (FLNB), and FLNA through specific filamin repeats, establishing essential connections that contribute to the intricate regulation of platelet function and hemostasis.

Immobilized Human CD42b, His Tag at 0.5 μg/mL (100μl/well) on the plate. Dose response curve for Anti-CD42b Antibody, hFc Tag with the EC₅₀ of <11.3 ng/mL determined by ELISA.

Human

HEK293

C-His

P07359 (H17-L531)

2811  [NCBI]

HPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPL

100-130 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.