GP1BA - glycoprotein Ib platelet subunit alpha Gene

Homo sapiens

Also known as BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha

Gene ID: 2811 | Gene type: protein coding

About GP1BA

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,932,277-4,935,023 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues, 22 paralogues and is associated with 8 phenotypes. Biased expression in lymph node (RPKM 7.8), spleen (RPKM 2.5) and 9 other tissues.

Summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

GP1BA Products(1)

mRNA	Protein	Name
NM_000173.7	NP_000164.5	platelet glycoprotein Ib alpha chain precursor

GP1BA Protein Structure

LRRNT

LRR_1

LRR_8

0
100
200
300
400
500
600
652 a.a.

Protein Preferred Names

Protein Names

platelet glycoprotein Ib alpha chain

GP-Ib alpha

Recombinant GP1BA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77951	CD42b/GP1BA Protein, Human (515a.a, HEK293, His)	P07359 (H17-L531)	≥95%

Related Diseases

Diseases

Alias

Pseudo-Von Willebrand Disease

Bdplt3	Von Willebrand Disease, Platelet-Type
VWDP	Platelet-Type Bleeding Disorder 3
Platelet Type-Von Willebrand Disease	Pt-Vwd
Von Willebrand Disease Platelet-Type	Von Willebrand Disease, Platelet Type
Pseudo Von Willebrand Disease	Bleeding Disorder, Platelet-Type, 3
Pseudo-Von Willebrand Disease Type 2b	Bleeding Disorder Platelet-Type 3
Pseudo-Vwd

Bernard-Soulier Syndrome, Type A2, Autosomal Dominant

BSSA2	Bernard-Soulier Syndrome Type A2
Bernard-Soulier Syndrome, Type A2	Bernard-Soulier Syndrome A2, Autosomal Dominant
Autosomal Dominant Benign Bernard-Soulier Syndrome	Benign Mediterranean Macrothrombocytopenia
Bernard-Soulier Syndrome, Benign Autosomal Dominant

Bernard-Soulier Syndrome

Giant Platelet Syndrome	BSS
Von Willebrand Factor Receptor Deficiency	Bdplt1
Platelet Glycoprotein Ib Deficiency	Bernard-Soulier Syndrome, Type A1
Bernard-Soulier Syndrome, Type B	Bernard Soulier Syndrome
Deficiency Of Platelet Glycoprotein 1b	Hemorrhagiparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type C	Bleeding Disorder, Platelet-Type, 1
Glycoprotein Ib, Platelet, Deficiency Of	Giant Platelet Disorder, Isolated
Giant Platelet Disease	Macrothrombocytopenia, Familial Bernard-Soulier Type
Bernard-Soulier Syndrome, Type C	Bernard - Soulier Thrombopathy
Hemorrhagic Dystrophic Thrombocytopenia	Thrombopathy, Bernard-Soulier
Platelet Glycoprotein 1b, Deficiency Of	Hemorrhagioparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type A1	Bernard-Soulier Syndrome Type B
Bleeding Disorder Platelet-Type 1	Gpd
Macrothrombocytopenia, Familial, Bernard-Soulier Type

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy	Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
NAION	Non-Arteritic Anterior Ischemic Optic Neuropathy
Ischemic Optic Neuropathy	Aion
Optic Neuropathy, Ischemic	Naion, Susceptibility To
Optic Neuropathy, Anterior Ischemic	Optic Neuropathy, Anterior Ischemic, Susceptibility To
Non-Arteritic Anterior Ischaemic Optic Neuropathy	Nonarteritic Anterior Ischaemic Optic Neuropathy
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To	Ion - [Ischemic Optic Neuropathy]
Neuropathic Ischaemia Of N.Opticus	Ischaemic Neuropathy Of Optic Nerve

Autosomal Dominant Macrothrombocytopenia

Fetal And Neonatal Alloimmune Thrombocytopenia

Nait	Neonatal Alloimmune Thrombocytopenia
Fnait

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Arteritic Anterior Ischemic Optic Neuropathy

Thrombosis

Thrombosis Of Blood Vessel

Von Willebrand'S Disease

Von Willebrand Disease	Von Willebrand Disorder
Vascular Pseudohemophilia	Hereditary Von Willebrand Disease
Vwd	Vascular Hemophilia
Von Willebrand'S-Jurgens' Disease	Von Willebrand-Jrgens Disease
Von Willebrand Factor Deficiency	Von Willebrand Factor, Deficiency
Angiohemophilia	Von Willebrand'S Factor Deficiency
Von Willebrand Diseases	Factor Viii Deficiency With Vascular Defect
Vascular Haemophilia	Willebrand Jurgen Thrombopathy
Pseudohaemophilia	Minot-Von Willebrand-Jurgen Disease
Angiohaemophilia	Angiohaemophilia A
Angiohaemophilia B

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Coronary Thrombosis

Coronary Artery Thrombosis

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura	Autoimmune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura	Itp
Idiopathic Purpura	AITP
Ideopath Thrombocytopenic Pur	Primary Thrombocytopenic Purpura
Werlhof'S Disease	Thrombocytopenic Purpura Autoimmune
Purpura Thrombocytopenic Idiopathic	Purpura, Thrombocytopenic, Idiopathic
Autoimmune Thrombocytopenia	Thrombocytopenia Due To Platelet Alloimmunization
Idiopathic Thrombocytopenia	Idiopathic Thrombocytopenia Purpura
Frank'S Essential Thrombocytopenia	Itp - [Idiopathic Thrombocytopenia Purpura]
Werlhof Disease	Primary Autoimmune Thrombocytopenic Purpura
Haemorrhagic Purpura	Essential Thrombocytopenia
Purpura Haemorrhagica

Ischemia

Acute Coronary Syndrome

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Neuropathy

Peripheral Neuropathy

Peripheral Neuropathies

Bleeding Disorder, Platelet-Type, 11

BDPLT11	Glycoprotein Vi Deficiency
Gp Vi Deficiency	Platelet-Type Bleeding Disorder 11
Bleeding Diathesis Due To A Collagen Receptor Defect	Bleeding Diathesis Due To Glycoprotein Vi Deficiency
Platelet-Type Bleeding Disorder-11	Bleeding Disorder, Platelet Type 11
Hemorrhage

Purpura

Purpuric Disorder

Endocarditis

Von Willebrand Disease, Type 1

Von Willebrand Disease Type 1	VWD1
Von Willebrand'S Disease 1	Von Willebrand Disease Type I
Von Willebrand Disease, Type I	Vwd, Type 1
Vwd Type 1	Von Willebrand Disease 1
Von Willebrand Factor Deficiency Type 1	Von Willebrand Disease, Type 1, Susceptibility To

Thrombasthenia

Acquired Thrombocytopenia

Secondary Thrombocytopenia

Von Willebrand Disease, Type 2

Von Willebrand Disease Type 2m	Von Willebrand Disease Type 2
Von Willebrand Disease Type 2a	Von Willebrand Disease Type 2b
Von Willebrand Disease Type 2n	VWD2
Von Willebrand'S Disease 2	Von Willebrand Disease Type Ii
Von Willebrand Disease, Type Ii	Vwd, Type 2
Von Willebrand Disease, Types 2a, 2b, 2m, And 2n	Vwd Type 2
Von Willebrand Disease 2	Von Willebrand Disease Normandy Variant
Von Willebrand Disease Type 2 Malmo	Von Willebrand Disease Type I New York
Von Willebrand Factor Deficiency Type 2	Vwd2a
Vwd2b	Vwd2m
Vwd2n	Von Willebrand Disease, Type 2a, 2b, 2m, And 2n
Von Willebrand Disease, Type 2a	Von Willebrand Disease, Type 2b
Von Willebrand Disease, Type 2n

Acquired Von Willebrand Syndrome

Acquired Von Willebrand Disease	Willebrand Disease, Acquired
Avws

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Von Willebrand Disease, Type 3

Von Willebrand Disease Type 3	VWD3
Von Willebrand'S Disease 3	Von Willebrand Disease Type Iii
Von Willebrand Disease, Type Iii	Vwd, Type 3
Vwd Type 3	Von Willebrand Disease 3
Von Willebrand Disease Recessive Form	Von Willebrand Factor Deficiency Type 3

Trimethoprim Allergy

Primsol Allergy	Proloprim Allergy
Tmp Allergy

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome	Hughes Syndrome
Familial Antiphospholipid Syndrome	Aps
Lupus Anticoagulant, Familial	Anti-Phospholipid Syndrome
Apls	Classic Apls
Classic Antiphospholipid Syndrome	Acromegaloid Facial Appearance Syndrome
Anticardiolipin Syndrome

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Erythroleukemia

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Myh-9 Related Disease

Myh9-Related Disease	Myh9-Rd
Myh9-Related Disorder	Myh9-Related Syndrome
Myh9-Related Syndromic Thrombocytopenia	Sebastian Syndrome

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia	Autoimmune Thrombocytopenia
Immune Thrombocytopenic Purpura	Itp
Auto-Immune Thrombocytopenia	Thrombocytopenia Due To Immune Destruction
Autoimmune Thrombocytopenic Purpura	Idiopathic Thrombocytopenic Purpura
Werlhof Disease

Blood Coagulation Disease

Blood Coagulation Disorders	Coagulation Protein Disease
Inherited Blood Coagulation Disease	Postpartum Coagulation Defect
Postpartum Coagulation Defect With Delivery	Coagulation Protein Disorders
Puerperal Coagulopathy

Arteriosclerosis

Arteriosclerotic Vascular Disease

Qualitative Platelet Defect

Qualitative Platelet Defects	Qualitative Platelet Deficiency
Thrombocytopathy	Platelet Defect
Platelet Disorder	Thrombopathy
Platelet Granule Defect	Thrombocytasthenia
Thromboasthenia	Dystrophic Thrombocytopathy
Haemorrhagic Thrombasthenia	Granulopenic Thrombocytopathy

Meckel Syndrome, Type 6

Meckel Syndrome 6	MKS6
Meckel-Gruber Syndrome, Type 6

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Carotid Artery Thrombosis

Infective Endocarditis

Bacterial Endocarditis	Endocarditis, Infective
Infectious Endocarditis	Endocarditis Infective

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Thrombotic Thrombocytopenic Purpura

Purpura, Thrombotic Thrombocytopenic	Ttp
Thrombotic Thrombocytopenic Purpura, Acquired	Idiopathic Thrombotic Thrombocytopenic Purpura
Moschcowitz Disease	Moschcowitz'S Syndrome
Moschowitz Syndrome	Chronic Relapsing Thrombotic Thrombocytopenic Purpura
Familial Thrombotic Thrombocytopenia Purpura	Moschkowitz Disease
Purpura Thrombotic Thrombocytopenic	Familial Thrombotic Thrombocytopenic Purpura
Microangiopathic Hemolytic Anemia	Congenital Thrombotic Thrombocytopenic Purpura
Autoimmune Thrombotic Thrombocytopenic Purpura	Ttp - [Thrombotic Thrombocytopenic Purpura]
Moschcowitz Syndrome

Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Acrokeratoderma, Hereditary Papulotranslucent

Hereditary Papulotranslucent Acrokeratoderma

Primary Thrombocytopenia

Amegakaryocytic Thrombocytopenia, Congenital

Congenital Amegakaryocytic Thrombocytopenia	CAMT
Thrombocytopenia, Congenital Amegakaryocytic	Congenital Amegakaryocytic Thrombocytopenic Purpura
Thrombocytopenia Congenital Amegakaryocytic	Thrombocytopenia, Amegakaryocytic, Congenital

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diabetes Mellitus

Diabetes

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05607	GP1BA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GP1BA	VGNC	VGNC:73113
Rattus norvegicus	GP1BA	RGD	RGD:1310239
Mus musculus	GP1BA	MGD	MGI:1333744
Felis catus	GP1BA	VGNC	VGNC:99070
Bos taurus	GP1BA	VGNC	VGNC:29504
Others	GP1BA	NCBI