1. GPCR/G Protein
  2. Neuropeptide Y Receptor

Neuropeptide Y Receptor

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.

Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.

Neuropeptide Y Receptor Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-14423
    Velneperit Antagonist 99.65%
    Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.
  • HY-100717
    HT-2157 Antagonist >98.0%
    HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
  • HY-14450
    JNJ-31020028 Antagonist 98.26%
    JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
  • HY-15411
    MK-0557 Antagonist 98.28%
    MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
  • HY-107382
    RF9 Antagonist 98.24%
    RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.
  • HY-P1025
    M40 Antagonist 98.25%
    M40 is a potent, non-selective galanin receptor antagonist.
  • HY-P0262
    Galantide Antagonist
    Galantide is a reversible and non-specific galanin receptor antagonist.
  • HY-U00335
    FR252384 Antagonist
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.