1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Neuropeptide Y Receptor

Neuropeptide Y Receptor

Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Related Products (77):

Cat. No. Product Name Effect Purity
  • HY-P1127
    Galanin (1-30), human
    Agonist 99.11%
    Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.
  • HY-100717
    HT-2157
    Antagonist ≥98.0%
    HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
  • HY-108625
    SHA 68
    Antagonist 98.05%
    SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
  • HY-107725
    BIBO3304 TFA
    Antagonist 99.95%
    BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
  • HY-14450
    JNJ-31020028
    Antagonist 98.62%
    JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
  • HY-107733
    NTNCB hydrochloride
    Antagonist 98.07%
    NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a Ki of 8 nM against human Y5.
  • HY-107726A
    BIBP3226
    Antagonist
    BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.
  • HY-P0049A
    Argipressin diacetate
    Activator
    Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.
  • HY-107726
    BIBP3226 TFA
    Antagonist 98.09%
    BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.
  • HY-P1021A
    Peptide YY (PYY) (3-36), porcine TFA
    Agonist 99.21%
    Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.
  • HY-107734
    L 152804
    Antagonist 99.48%
    L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
  • HY-107382
    RF9
    Antagonist 98.66%
    RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
  • HY-107723
    CGP71683 hydrochloride
    Antagonist 99.12%
    CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
  • HY-120619
    BMS-193885
    Antagonist 99.08%
    BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively .
  • HY-P0198A
    Neuropeptide Y (human) (TFA)
    98.84%
    Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
  • HY-15411
    MK-0557
    Antagonist 99.84%
    MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
  • HY-P2543
    Neuropeptide Y (3-36) (human, rat)
    Agonist
    Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.
  • HY-14423
    Velneperit
    Antagonist 99.50%
    Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.
  • HY-P1723
    Spexin
    Agonist 98.10%
    Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin peptide contains numerous aromatic amino acids and is probably amidated.
  • HY-P1323A
    [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA
    Agonist 99.38%
    [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.