1. GPCR/G Protein
  2. Neuropeptide Y Receptor

Neuropeptide Y Receptor

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.

Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.

Neuropeptide Y Receptor Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-14423
    Velneperit Antagonist 99.65%
    Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.
  • HY-100717
    HT-2157 Antagonist >98.0%
    HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
  • HY-15411
    MK-0557 Antagonist 98.28%
    MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
  • HY-14450
    JNJ-31020028 Antagonist
    JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
  • HY-P1601
    Neuropeptide Y(29-64)
    Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.
  • HY-P1578
    Galanin (1-16), mouse, porcine, rat Agonist
    Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
  • HY-P1537
    Pancreatic Polypeptide, bovine Agonist
    Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
  • HY-101986
    BIIE-0246 Antagonist
    BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 of 15±3 nM.
  • HY-P1127
    Galanin (1-30), human Agonist
    Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.
  • HY-P1532
    Pancreatic Polypeptide, rat Agonist
    Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.
  • HY-P1480
    Neuropeptide Y (13-36), amide, human Agonist
    Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.
  • HY-P0198
    Neuropeptide Y (29-64), amide, human
    Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.
  • HY-P1514
    Peptide YY (PYY), human
    Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
  • HY-P0199
    Pancreatic Polypeptide, human Agonist
    Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
  • HY-107382
    RF9 Antagonist 98.24%
    RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.
  • HY-P1025
    M40 Antagonist 98.25%
    M40 is a potent, non-selective galanin receptor antagonist.
  • HY-P0262
    Galantide Antagonist
    Galantide is a reversible and non-specific galanin receptor antagonist.
  • HY-U00335
    FR252384 Antagonist
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
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