1. GPCR/G Protein
  2. Neuropeptide Y Receptor

MK-0557 

Cat. No.: HY-15411 Purity: 98.28%
Data Sheet SDS Handling Instructions

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.

For research use only. We do not sell to patients.
MK-0557 Chemical Structure

MK-0557 Chemical Structure

CAS No. : 328232-95-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $154 In-stock
5 mg $140 In-stock
10 mg $220 In-stock
50 mg $660 In-stock
100 mg $1100 In-stock
200 mg $1600 In-stock
500 mg   Get quote  
1 g   Get quote  

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Description

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.

IC50 & Target

Ki: 1.6 nM (Y5)[1]

In Vitro

MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction in body-weight gain at day 35[2].

In Vivo

MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4606 mL 12.3028 mL 24.6057 mL
5 mM 0.4921 mL 2.4606 mL 4.9211 mL
10 mM 0.2461 mL 1.2303 mL 2.4606 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

406.41

Formula

C₂₂H₁₉FN₄O₃

CAS No.

328232-95-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
MK-0557
Cat. No.:
HY-15411
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