NPY Y2 receptor
NPY Y2 receptor is a widely distributed Gi/Go-coupled GPCR that inhibits adenylate cyclase, reduces cAMP accumulation, and modulates Ca2+/K+ channel signaling[1][2]. Mechanistically, Y2 signaling supports presynaptic inhibition by neuropeptide Y (NPY) and peptide YY (PYY), linking receptor activation to reduced neuronal excitability and regulated neurotransmitter release[1][3]. In disease models, Y2 receptor biology connects to feeding control, anxiety-related behavior, epilepsy research, neuroblastoma, and obesity-relevant experimental designs[1][4]. Compared with related isoforms, Y2 receptor selectivity depends on ligand structure and receptor subtype pharmacology, distinguishing it from Y1, Y4, and Y5 receptors in assay design[2][5]. For experimental applications, Y2-selective agonists can inhibit food intake and promote fat metabolism in mice, while nonpeptidic Y2 antagonists such as SF-11 provide brain-penetrant tools for behavioral studies[4][6].- Y2 receptor assays should prioritize Gi/Go signaling, cAMP inhibition, and subtype-selective ligand validation[2][5].- Feeding, anxiety, epilepsy, and neuroblastoma models provide practical contexts for NPY2R study[1][4].- Agonists and antagonists support mechanistic experiments when receptor selectivity is experimentally confirmed[5][6].
References:
- [1]. Parker SL, et al. Neuropeptide Y Y2 receptor in health and disease. Br J Pharmacol. 2008 Feb;153(3):420-31. [Content Brief]
- [2]. Pedragosa-Badia X, et al. Neuropeptide Y receptors: how to get subtype selectivity. Front Endocrinol (Lausanne). 2013 Feb 4;4:5. [Content Brief]
- [3]. Kang H, et al. Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure. 2023 Jan 5;31(1):44-57.e6. [Content Brief]
- [4]. Balasubramaniam A, et al. Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: combined anorectic effects of Y2 and Y4 receptor-selective agonists. Peptides. 2007 Feb;28(2):235-40. [Content Brief]
- [5]. Mittapalli GK, et al. Ligands of the neuropeptide Y Y2 receptor. Bioorg Med Chem Lett. 2014 Jan 15;24(2):430-41. [Content Brief]
- [6]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019 Aug 21;10(8):3454-3463. [Content Brief]
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NPY Y2 receptor Related Products (23)
Related Products (23)
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BIIE-0246
0 ImagesSynonyms: AR-H 053591BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
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Peptide YY (PYY) (3-36), Human
0 ImagesPeptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.
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RF9
0 ImagesRF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
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Neuropeptide Y (3-36) (human, rat)
0 ImagesCat. No.: HY-P2543CAS No.: 150138-78-6Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides[1][2].
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Neuropeptide Y (13-36), amide, human
0 ImagesSynonyms: Neuropeptide Y (13-36), humanNeuropeptide Y (13-36), amide, human is a selective neuropeptide Y2 receptor agonist.
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NNC0165-1273 acetate
0 ImagesCat. No.: HY-P11291BPurity: 99.78%NNC0165-1273 acetate is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 acetate blocks Ghrelin-induced cFos expression. NNC0165-1273 acetate reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 acetate reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 acetate can be used in studies related to diet-induced obesity.
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CYM 9484
0 ImagesCYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.
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SF 11
0 ImagesSF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity.
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
![[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide](https://file.medchemexpress.com/product_pic/hy-p1324.gif "Click to View [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Product Detail")
0 Images[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.
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(Leu31,Pro34)-Peptide YY (human) TFA
0 ImagesCat. No.: HY-P3877APurity: 98.63%(Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) (HY-P3877). (Leu31,Pro34)-Peptide YY (human) (TFA) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
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JNJ-5207787
0 ImagesJNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors.
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NNC0165-1273 TFA
0 ImagesCat. No.: HY-P11291ANNC0165-1273 TFA is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 TFA blocks Ghrelin-induced cFos expression. NNC0165-1273 TFA reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 TFA reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 TFA can be used in studies related to diet-induced obesity.
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RF9 hydrochloride
0 ImagesCat. No.: HY-107382APurity: 99.91%RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
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(Leu31,Pro34)-Peptide YY (human)
0 ImagesCat. No.: HY-P3877CAS No.: 179986-95-9(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
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GEP44
0 ImagesCat. No.: HY-P11043GEP44 is a peptide biased triple agonist targeting Glucagon-like peptide 1 receptor (GLP-1R), neuropeptide Y1 Receptor (Y1-R), and neuropeptide Y2 Receptor (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research.
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NNC0165-1273
0 ImagesCat. No.: HY-P11291NNC0165-1273 is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 blocks Ghrelin-induced cFos expression. NNC0165-1273 reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 can be used in studies related to diet-induced obesity.
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BWX 46
0 ImagesCat. No.: HY-P1325CAS No.: 172997-92-1Synonyms: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2BWX 46 (((Cys31, Nva 34)-Neuropeptide Y (27-36))2) is a selective Y5 receptor agonist with an IC50 value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y5 cells.
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
![[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA](https://file.medchemexpress.com/product_pic/hy-p1324a.gif "Click to View [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA Product Detail")
0 ImagesCat. No.: HY-P1324A[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.
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Peptide YY (pig)
0 ImagesCat. No.: HY-P2703CAS No.: 81858-94-8Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system.
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(R)-JNJ-31020028
0 ImagesCat. No.: HY-107479CAS No.: 1094873-17-2(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.
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