1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RF9

RF9 

Cat. No.: HY-107382 Purity: 98.66%
Handling Instructions

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

For research use only. We do not sell to patients.

RF9 Chemical Structure

RF9 Chemical Structure

CAS No. : 876310-60-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

IC50 & Target[1]

hNPFF1R

58 nM (Ki)

hNPFF2R

75 nM (Ki)

In Vitro

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1].
Dosage: 0.1 mg/kg.
Administration: S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result: Opposed to delaye heroin-induced hyperalgesia and associated tolerance.
Molecular Weight

482.62

Formula

C₂₆H₃₈N₆O₃

CAS No.

876310-60-0

SMILES

NC([[email protected]](CC1=CC=CC=C1)NC([[email protected]](CCCNC(N)=N)NC(C23C[[email protected]](C4)C[[email protected]](C[[email protected]]4C3)C2)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (259.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0720 mL 10.3601 mL 20.7202 mL
5 mM 0.4144 mL 2.0720 mL 4.1440 mL
10 mM 0.2072 mL 1.0360 mL 2.0720 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RF9RF 9RF-9Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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Product Name:
RF9
Cat. No.:
HY-107382
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