1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RF9

RF9 

Cat. No.: HY-107382
Handling Instructions

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.

For research use only. We do not sell to patients.

RF9 Chemical Structure

RF9 Chemical Structure

CAS No. : 876310-60-0

Size Price Stock
10 mM * 1 mL in DMSO USD 242 Ask For Quote & Lead Time
1 mg USD 108 Ask For Quote & Lead Time
5 mg USD 228 Ask For Quote & Lead Time

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Description

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.

IC50 & Target

Ki: 58±5 nM (hNPFF1R), 75±9 nM (hNPFF2R)[1]

In Vivo

RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1]. It is worthy to note that RF9 (30 nmol) significantly reduces the hypothermia induced by morphine (5 nmol)[2].

Molecular Weight

482.62

Formula

C₂₆H₃₈N₆O₃

CAS No.

876310-60-0

SMILES

NC([[email protected]](CC1=CC=CC=C1)NC([[email protected]](CCCNC(N)=N)NC(C23C[[email protected]](C4)C[[email protected]](C[[email protected]]4C3)C2)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (310.80 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0720 mL 10.3601 mL 20.7202 mL
5 mM 0.4144 mL 2.0720 mL 4.1440 mL
10 mM 0.2072 mL 1.0360 mL 2.0720 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats: Rats (n=5) are catheterized for measurement of arterial blood pressure and receive an in-dwelling cannula into the lateral cerebral ventricle. Arterial blood pressure and heart rate are continuously monitored. NPFF (10 μg in 10 μL of saline) is injected into the lateral ventricle over 15 to 20 sec. Control injections of saline (10 μL) are carried out in the same animals. Upon return of blood pressure to baseline, RF9 (10 μg) is injected i.c.v., followed by another i.c.v. injection of NPFF with RF9. After 1.5 h., another i.c.v. infusion of NPFF is repeated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

RF9RF 9RF-9Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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