876310-60-0
876310-60-0
Chemical Structure
RF9
- CAS No.: 876310-60-0
- Formula:C26H38N6O3
- Molecular Weight:482.62
IUPAC Name: (3S,5S,7S)-N-((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)adamantane-1-carboxamide
InChIKey: UMKHUSRDQFQHAK-XIXLPFSXSA-N
SMILES: NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)C[C@H](C[C@H]4C3)C2)=O)=O)=O
Biological Activity: RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RF9 | 99.37% | RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. | ||||||||||||||||||||
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RF9 (Standard) | RF9 (Standard) is the analytical standard of RF9 (HY-107382). This product is intended for research and analytical applications. RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. | |||||||||||||||||||||
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References
- [1]. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. [Content Brief]
- [2]. Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643. [Content Brief]
Keywords
