D-Pro-Phe-Arg-Chloromethylketone

Art. -Nr.: HY-P4245 Reinheit: 99.24%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation.

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Kundenspezifische Peptidsynthese

D-Pro-Phe-Arg-Chloromethylketone Chemische Struktur

CAS. Nr. : 88546-74-1

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE D-Pro-Phe-Arg-Chloromethylketone

•Immunity. 2026 Jun 9;59(6):1651-1666.e8. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Kallikrein Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation^[1].

Molekulargewicht

450.96

Formel

C₂₁H₃₁ClN₆O₃

CAS. Nr.

88546-74-1

Appearance

Solid

Color

White to off-white

Sequence

{d-Pro}-Phe-{Arg-Chloromethylketone}

Sequence Shortening

{d-Pro}-F-{Arg-Chloromethylketone}

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (221.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2175 mL	11.0875 mL	22.1749 mL
5 mM	0.4435 mL	2.2175 mL	4.4350 mL
10 mM	0.2217 mL	1.1087 mL	2.2175 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.51%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (111 KB) MS (212 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2175 mL	11.0875 mL	22.1749 mL	55.4373 mL
	5 mM	0.4435 mL	2.2175 mL	4.4350 mL	11.0875 mL
	10 mM	0.2217 mL	1.1087 mL	2.2175 mL	5.5437 mL
	15 mM	0.1478 mL	0.7392 mL	1.4783 mL	3.6958 mL
	20 mM	0.1109 mL	0.5544 mL	1.1087 mL	2.7719 mL
	25 mM	0.0887 mL	0.4435 mL	0.8870 mL	2.2175 mL
	30 mM	0.0739 mL	0.3696 mL	0.7392 mL	1.8479 mL
	40 mM	0.0554 mL	0.2772 mL	0.5544 mL	1.3859 mL
	50 mM	0.0443 mL	0.2217 mL	0.4435 mL	1.1087 mL
	60 mM	0.0370 mL	0.1848 mL	0.3696 mL	0.9240 mL
	80 mM	0.0277 mL	0.1386 mL	0.2772 mL	0.6930 mL
	100 mM	0.0222 mL	0.1109 mL	0.2217 mL	0.5544 mL