1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Piezo Channel

Piezo Channel

Piezo channels are the trimeric mechanosensitive ion channels that open in response to mechanical stimuli such as shear stress and membrane stretch, allowing positively charged ions, including calcium, to flow into the cell. It is speculated that extracellular mechanical stimuli can be converted into tension from lipid molecules in the cell membrane to activate the Piezo channels. The intracellular beam might transmit tension from lipid molecules from the distal blade to the central pore module by means of a lever principle, which opens the central pore for ion-conducting. Most vertebrates have two channel isoforms, Piezo1 and Piezo2. Piezo1 and Piezo2 are involved in various mechanotransduction pathways, including touch sensation, proprioception, nociception, vascular development, and breathing. In humans, gain-of-function mutations in Piezo1 are linked to dehydrated hereditary stomatocytosis (DHS). Loss-of-function mutations in Piezo1 and Piezo2 are linked to congenital lymphatic dysplasia14 and defective touch perception and proprioception.

Piezo Channel Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-18723
    Yoda 1
    Agonist 99.98%
    Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda1 induces activation of both Akt and ERK1/2 in endothelial cells (ECs), which is not dependent on Piezo1. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.
  • HY-P1410A
    GsMTx4 TFA
    Inhibitor 98.29%
    GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
  • HY-P1410
    GsMTx4
    Inhibitor 99.48%
    GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
Isoform Specific Products

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