1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 98.86%
    AG-490 is an tyrosine kinase inhibitor, inhibits EGFR and Stat-3.
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 is a chemical probe inhibitor of Stat3 activity, selectively inhibits Stat3 DNA-binding activity in vitro with IC50 of 86±33 μM.
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic is a potent inhibitor of STAT3, used for cancer treatment.
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone(Tanshinone c) is a potent STAT3 inhibitor(IC50 =4.6 uM); inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells.
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin is a newly found small molecule with the ability to inhibit gene transcription of STAT3, which is able to suppress cancer stemness properties and induce cell death.
  • HY-N0622
    Morusin Inhibitor 99.08%
    Morusin is a prenylated flavonoid isolated from M.
  • HY-N0193
    Artesunate Inhibitor
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
  • HY-100602
    HJC0152 hydrochloride Inhibitor
    HJC0152 hydrochloride is a signal transducers and activators of transcription 3 (STAT3) inhibitor.
  • HY-14944
    Homoharringtonine Inhibitor 98.71%
    Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree.
  • HY-15312
    WP1066 Inhibitor 99.67%
    WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2, but not JAK1 and JAK3.
  • HY-B0497
    Niclosamide Inhibitor 98.88%
    Niclosamide is an inhibitor of STAT with IC50 of 0.7 μM and inhibits DNA replication in a cell-free assay.
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1.
  • HY-100453
    HO-3867 Inhibitor 99.38%
    HO-3867 a selective and potent inhibit STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
  • HY-101853
    STAT5-IN-1 Inhibitor >98.0%
    STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
  • HY-100493
    BP-1-102 Inhibitor 99.23%
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3.
  • HY-N0156
    Oleanolic Acid Inhibitor >98.0%
    Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
  • HY-B1436
    Nifuroxazide Inhibitor >98.0%
    Nifuroxazide is an inhibitor of STAT activation and signaling activity, is an oral nitrofuran antibiotic, used to treat colitis and diarrhea in humans and non-humans.
  • HY-N0897
    Corylifol A Inhibitor 99.75%
    Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).