1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT Isoform Specific Products:

  • STAT3

  • STAT5

  • STAT6

STAT Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 99.84%
    AG-490 is an tyrosine kinase inhibitor, inhibits EGFR and Stat-3.
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic is a potent inhibitor of STAT3 activation and dimerization.
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 is a chemical probe inhibitor of Stat3 activity, selectively inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 μM.
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone is a potent STAT3 inhibitor with IC50 of 4.6 μM, and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells.
  • HY-112288
    C188-9 Inhibitor 98.11%
    C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
  • HY-P1061A
    Colivelin TFA Activator
    Colivelin (TFA) is a neuroprotective peptide and activator of STAT3.
  • HY-N6651
    Isocryptotanshinone Inhibitor
    Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.
  • HY-15312
    WP1066 Inhibitor 99.67%
    WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells.
  • HY-14944
    Homoharringtonine Inhibitor 99.39%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
  • HY-101853
    STAT5-IN-1 Inhibitor >98.0%
    STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
  • HY-B0497
    Niclosamide Inhibitor
    Niclosamide is an inhibitor of STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54 is a most potent, small molecule, nonphosphorylated STAT inhibitor, with KDs of 300, 464 nM for STAT3 and STAT5, respectively.
  • HY-100493
    BP-1-102 Inhibitor 99.23%
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
  • HY-100453
    HO-3867 Inhibitor 99.38%
    HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor.
  • HY-N0751
    Scutellarin Inhibitor >98.0%
    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
  • HY-N0193
    Artesunate Inhibitor >98.0%
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
  • HY-B1436
    Nifuroxazide Inhibitor 99.20%
    Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.