1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT Isoform Specific Products:

  • STAT3

  • STAT5

STAT Related Products (37):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 99.84%
    AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic is a potent inhibitor of STAT3 activation and dimerization.
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 is a potent STAT6 inhibitor with an IC50 of 21 nM.
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 is a selective Stat3 inhibitor with an IC50 of 86±33 μM.
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
  • HY-P1061A
    Colivelin TFA Activator
    Colivelin (TFA) is a neuroprotective peptide and activator of STAT3. Sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro;SALLRSIPAPAGASRLLLLTGEIDLP.
  • HY-N6651
    Isocryptotanshinone Inhibitor
    Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.
  • HY-N0516
    Casticin Inhibitor
    Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells.
  • HY-15312
    WP1066 Inhibitor 99.67%
    WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
  • HY-101853
    STAT5-IN-1 Inhibitor >98.0%
    STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
  • HY-14944
    Homoharringtonine Inhibitor 99.39%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
  • HY-B0497
    Niclosamide Inhibitor
    Niclosamide?is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free a
  • HY-100493
    BP-1-102 Inhibitor 99.23%
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
  • HY-N0751
    Scutellarin Inhibitor >98.0%
    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.
  • HY-100453
    HO-3867 Inhibitor 99.38%
    HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity.
  • HY-N0193
    Artesunate Inhibitor >98.0%
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
  • HY-N1405
    Cucurbitacin I Inhibitor >98.0%
    Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
  • HY-12987
    Pimozide Inhibitor 99.88%
    Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.