1. Signaling Pathways
  2. JAK/STAT Signaling
    Stem Cell/Wnt
  3. STAT
  4. STAT5 Isoform

STAT5

 

STAT5 Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-101853
    STAT5-IN-1
    Inhibitor ≥98.0%
    STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
  • HY-12987
    Pimozide
    Inhibitor 99.88%
    Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
  • HY-124500
    AC-4-130
    Inhibitor 99.87%
    AC-4-130 is a potent STAT5 SH2 domain inhibitor.
  • HY-16975
    SH-4-54
    Inhibitor 99.59%
    SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.
  • HY-126675A
    AS2863619
    Activator ≥98.0%
    AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases.
  • HY-151634
    Syk-IN-6
    Inhibitor
    Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain.
  • HY-19527
    IST5-002
    Inhibitor
    IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b).
  • HY-102048
    STAT5-IN-2
    Inhibitor 99.01%
    STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f.
  • HY-13072
    Cenisertib
    Inhibitor 99.64%
    Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3.
  • HY-120395
    UC-514321
    Inhibitor ≥98.0%
    UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3.
  • HY-136546
    Stafia-1
    Inhibitor 99.53%
    Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM).
  • HY-126675
    AS2863619 free base
    Activator ≥98.0%
    AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases.
  • HY-131140
    BD750
    Inhibitor 99.79%
    BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.
  • HY-112647
    Stafib-1
    Inhibitor ≥98.0%
    Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.
  • HY-Y0493
    HODHBt
    Inhibitor ≥98.0%
    HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5.
  • HY-136568
    Stafia-1-dipivaloyloxymethyl ester
    Inhibitor 98.31%
    Stafia-1-dipivaloyloxymethyl ester (compound 27, 0-200 μM) decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.
  • HY-12987S
    Pimozide-d4
    Inhibitor
    Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide.