1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. SH-4-54

SH-4-54 

Cat. No.: HY-16975 Purity: 99.59%
Handling Instructions

SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.

For research use only. We do not sell to patients.

SH-4-54 Chemical Structure

SH-4-54 Chemical Structure

CAS No. : 1456632-40-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 226 In-stock
Estimated Time of Arrival: December 31
2 mg USD 114 In-stock
Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
25 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1092 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SH-4-54 purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2017 Mar 4;484(2):311-317.

    SGC7901 cells are pretreated with IL-6 neutralizing antibody or SH-4-54 for an hour prior to Tipα stimulation. STAT3 (Y705) phosphorylation is significantly inhibited by IL-6 antibody or SH-4-54 pretreatment.

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    Description

    SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.

    IC50 & Target

    STAT3

    300 nM (Kd)

    STAT5

    464 nM (Kd)

    In Vitro

    SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    610.59

    Formula

    C₂₉H₂₇F₅N₂O₅S

    CAS No.

    1456632-40-8

    SMILES

    O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (163.78 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6378 mL 8.1888 mL 16.3776 mL
    5 mM 0.3276 mL 1.6378 mL 3.2755 mL
    10 mM 0.1638 mL 0.8189 mL 1.6378 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.59%

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    Keywords:

    SH-4-54STATInhibitorinhibitorinhibit

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    Product Name:
    SH-4-54
    Cat. No.:
    HY-16975
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