1. Signaling Pathways
  2. JAK/STAT Signaling
    Stem Cell/Wnt
  3. STAT
  4. STAT3 Isoform
  5. STAT3 Inhibitor

STAT3 Inhibitor

STAT3 Inhibitors (79):

Cat. No. Product Name Effect Purity
  • HY-13818
    Stattic
    Inhibitor 98.92%
    Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727).
  • HY-16141
    Cilengitide
    Inhibitor 99.70%
    Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively.
  • HY-14944
    Homoharringtonine
    Inhibitor 99.96%
    Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.
  • HY-B0497
    Niclosamide
    Inhibitor 99.90%
    Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research.
  • HY-112288
    C188-9
    Inhibitor 99.90%
    C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM.
  • HY-148692
    OSM-SMI-10B
    Inhibitor 99.28%
    OSM-SMI-10B a derivative of OSM-SMI-10.
  • HY-19536
    LLL12
    Inhibitor
    LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation.
  • HY-10074
    TPCA-1
    Inhibitor 99.72%
    TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM.
  • HY-13919
    Napabucasin
    Inhibitor 99.27%
    Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells.
  • HY-N0193
    Artesunate
    Inhibitor 98.09%
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
  • HY-129602
    SD-36
    Inhibitor 99.46%
    SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members.
  • HY-15312
    WP1066
    Inhibitor 99.90%
    WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
  • HY-12000
    AG490
    Inhibitor 99.97%
    AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
  • HY-12987
    Pimozide
    Inhibitor 99.88%
    Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
  • HY-100493
    BP-1-102
    Inhibitor 98.98%
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
  • HY-129603
    SI-109
    Inhibitor 99.48%
    SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity.
  • HY-15146
    NSC 74859
    Inhibitor 98.64%
    NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM.
  • HY-N0038
    Alantolactone
    Inhibitor 99.94%
    Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity.
  • HY-100753
    STAT3-IN-1
    Inhibitor
    STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively.
  • HY-16975
    SH-4-54
    Inhibitor 99.59%
    SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.