19983-44-9
19983-44-9
Chemical Structure
Stattic
- CAS No.: 19983-44-9
- Formula:C8H5NO4S
- Molecular Weight:211.19
IUPAC Name: 6-nitrobenzo[b]thiophene 1,1-dioxide
InChIKey: ZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]
Biological Activity: Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Stattic | 99.58% | Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice. | ||||||||||||||||||||
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Stattic (Standard) | ≥98% | Stattic (Standard) is the analytical standard of Stattic. This product is intended for research and analytical applications. Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice. | ||||||||||||||||||||
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References
- [1]. Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12. [Content Brief]
- [2]. John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4. [Content Brief]
- [3]. Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223. [Content Brief]
Keywords
