2. Metabolic Enzyme/Protease
  3. Phosphoglycerate Dehydrogenase (PHGDH)
  4. PHGDH-IN-5

PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells.

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PHGDH-IN-5 Chemical Structure

PHGDH-IN-5 Chemical Structure

CAS No. : 17402-86-7

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PHGDH-IN-5 Related Antibodies

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Description

PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1].

IC50 & Target

IC50: 0.29 μM (PHGDH)[1].
In Vitro

PHGDH-IN-5 can inhibit the proliferation of MDA-MB-468, NCI-H1975, HT1080, and PC9 cells, with IC50 values ranging from 9.93 μM to 21.2 μM[1].
PHGDH-IN-5 (10-30 μM) reduces the production of M+3-serine derived from 13C6-glucose in MDA-MB-468 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHGDH-IN-5 Related Antibodies
Molecular Weight

211.19

Formula

C8H5NO4S
CAS No.
SMILES

O=S1(C2=CC=CC([N+]([O-])=O)=C2C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PHGDH-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHGDH-IN-517402-86-7Phosphoglycerate Dehydrogenase (PHGDH)MDA-MB-468、NCI-H1975、HT1080PC9cancerInhibitorinhibitorinhibit

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