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  5. IL-27

IL-27

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IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28[1]. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity. IL-27 shows pro- and anti-inflammatory, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, particularly with regards to inhibition of Th2, Th17 and Treg differentiation, and that has diverse effects on innate immune cells[2]. IL-27 activates STAT1, STAT3, STAT6, ERK and p38 MAPKs, and Akt, resulting in enhanced cell proliferation[3]. IL-27 drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR[4].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73199
    IL-27 Protein, Human (CHO, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Human CHO
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Human (CHO, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (229 amino acids (M1-K229)) and IL27A (214 amino acids (F29-P243)), is produced by CHO cells.
  • HY-P73200
    IL-27 Protein, Mouse (228a.a, HEK293, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Mouse (228a.a, HEK293, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (228 amino acids (M1-P228)) and IL27A (205 amino acids (F29-S234)), and is produced by HEK293 cells.
  • HY-P700118AF
    Animal-Free IL-27 beta/EBI3 Protein, Human (His)

    Interleukin-27 subunit alpha; IL-27-A; Interleukin-27 subunit beta; IL-27B; Epstein-Barr virus-in_x0002_duced gene 3 protein; EBV-induced gene 3 protein; EBI3; p28; Interleukin-30; IL-30

    		Human E. coli
    The IL-27 beta/EBI3 Protein, in conjunction with IL27, forms the IL-27 interleukin, pivotal in innate immunity. Possessing dual pro- and anti-inflammatory properties, IL-27 regulates T-helper cell development, inhibits T-cell proliferation, stimulates cytotoxic T-cell activity, induces B-cell isotype switching, and impacts innate immune cells. Under IL-27 influence, CD4 T-helper cells differentiate into TH1, TH2, and TH17 cells. IL-27 promotes rapid clonal expansion of naive CD4 T-cells, synergizes with IL-12 for IFN-gamma production, and contributes to antitumor and antiangiogenic activities through WSX-1/TCCR receptor activation. It forms heterodimers with IL27/IL27A (IL-27) and IL12A (IL-35), with no disulfide linkage, and interacts with SQSTM1. Animal-Free IL-27 beta/EBI3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-27 beta/EBI3 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-27 beta/EBI3 Protein, Human (His) is 209 a.a., with molecular weight of ~24.25 kDa.
  • HY-P700202AF
    Animal-Free IL-27 EBI3 Protein, Mouse (His)

    Interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein homolog

    		Mouse E. coli
    IL-27 Proteinas, along with IL23A, forms the IL-23 interleukin, a key cytokine in innate and adaptive immunity. It's implicated in infection response, binding to the IL12RB1 and IL23R receptor complex, activating Jak-Stat signaling. IL-23 stimulates memory T-cells, promoting pro-inflammatory cytokine production. It contributes to autoimmune inflammation and is implicated in tumorigenesis. IL-12, a growth factor for activated T and NK cells, enhances NK cell lytic activity and stimulates interferon-gamma production by resting PBMC. Animal-Free IL-27 EBI3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-27 EBI3 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-27 EBI3 Protein, Mouse (His) is 206 a.a., with molecular weight of ~23.84 kDa.
  • HY-P73200A
    IL-27 Protein, Mouse (228a.a, HEK293, C-His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 Proteinas, along with IL23A, forms the IL-23 interleukin, a key cytokine in innate and adaptive immunity. It's implicated in infection response, binding to the IL12RB1 and IL23R receptor complex, activating Jak-Stat signaling. IL-23 stimulates memory T-cells, promoting pro-inflammatory cytokine production. It contributes to autoimmune inflammation and is implicated in tumorigenesis. IL-12, a growth factor for activated T and NK cells, enhances NK cell lytic activity and stimulates interferon-gamma production by resting PBMC. IL-27 Protein, Mouse (228a.a, HEK293, C-His) is a recombinant protein dimer complex containing IL-27 Protein and IL-27A, expressed by HEK293 , with C-10*His labeled tag and GSGSGGSGGSGSGKL peptide. IL-27 Protein, Mouse (228a.a, HEK293, C-His), has molecular weight of ~57.6 kDa.
  • HY-P73200Y
    IL-27 Protein, Mouse (228a.a, HEK293, His, solution)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
  • HY-P72554
    IL-27 Protein, Mouse (HEK293, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Mouse (HEK293, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (209 amino acids (Y19-P228)) and IL27A (205 amino acids (F29-S234)), and is produced by HEK293 cells.
  • HY-P700122AF
    Animal-Free IL-30/IL-27A Protein, Human (His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Human E. coli
    IL-30/IL-27A Protein, in collaboration with EBI3, forms IL-27, a pivotal cytokine in innate immunity with pro- and anti-inflammatory properties. Regulating T-helper cell development, inhibiting T-cell proliferation, and impacting various immune cells, IL-27 influences CD4 T-helper cell differentiation and prompts rapid clonal expansion. It synergizes with IL-12, binds to WSX-1/TCCR for signal transduction, and suppresses TH2 and TH17 differentiation. Beyond immunomodulation, IL-27 exhibits antitumor, antiangiogenic, and antiviral activities, crucially dependent on its heterodimeric structure with EBI3. Animal-Free IL-30/IL-27A Protein, Human (His) is the recombinant human-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-30/IL-27A Protein, Human (His) is 215 a.a., with molecular weight of ~25.47 kDa.
  • HY-P700206AF
    Animal-Free IL-30/IL-27A Protein, Mouse (His)

    IL-27 p28 subunit; IL-27 subunit alpha; IL27; IL-27; IL27A; IL-27-A; IL27-A; IL27p28; IL30; interleukin 27; interleukin 30; interleukin-27 subunit alpha; MGC71873; p28IL-27A

    		Mouse E. coli
    IL-30/IL-27A Proteinas, an integral Ragulator complex component, crucially senses amino acids and activates mTORC1 for cell growth regulation in response to diverse cues. Lysosomal V-ATPase and the Ragulator complex, acting as a GEF for Rag GTPases, facilitate amino acid activation. Ragulator and Rag GTPases, including LAMTOR2, recruit and activate mTORC1 on lysosomes. LAMTOR2, part of the Ragulator complex, interacts with mTORC1, Rag GTPases, and lysosomal amino acid sensor SLC38A9, contributing to growth and nutrient sensing pathways, including the lysosomal folliculin complex. Animal-Free IL-30/IL-27A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-30/IL-27A Protein, Mouse (His) is 206 a.a., with molecular weight of ~24.51 kDa.
Cat. No. Product Name Effect Purity