IL-27 beta/EBI3
Interleukin-27 subunit beta, better known as Epstein-Barr virus-induced gene 3 (EBI3, IL-27B), is a 34 kDa soluble glycoprotein homologous to the p40 subunit of IL-12, originally identified as a gene strongly upregulated in B lymphocytes infected with Epstein-Barr virus. EBI3 lacks a membrane anchor and shares only 27% sequence identity with p40, yet adopts a similar soluble cytokine receptor-like fold with one Ig domain and two fibronectin type III domains. EBI3 is the shared beta subunit of three heterodimeric cytokines: IL-27 (with p28), IL-35 (with p35) and IL-39 (with p19). Through these pairings it participates in strikingly different immunology-antiviral and antitumor Th1 promotion via IL-27, Treg-mediated suppression via IL-35, and pro-inflammatory B cell activity via IL-39. EBI3 is expressed by dendritic cells, monocytes, endothelial cells and trophoblasts, is induced by RANKL in osteoclastogenesis, and is elevated in inflammatory bowel disease, rheumatoid arthritis and various carcinomas.
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IL-27 beta/EBI3 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
