1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase

Xanthine Oxidase

Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.

Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.

Xanthine Oxidase Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-N0196
    Baicalein Inhibitor >98.0%
    Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 mM.
  • HY-14874
    Topiroxostat Inhibitor 98.54%
    Topiroxostat(FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM.
  • HY-14268
    Febuxostat Inhibitor 99.90%
    Febuxostat(TEI 6720;TMX 67 ) is selective xanthine oxidase inhibitor with Ki of 0.6 nM.
  • HY-B0219
    Allopurinol Inhibitor >99.0%
    Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
  • HY-B1135
    Benzbromarone Inhibitor 99.17%
    Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout.
  • HY-12136
    Purpurogallin Inhibitor
    Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.
  • HY-N0814
    Phytic acid Inhibitor
    Phytic acid is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
  • HY-N0814A
    Phytic acid dodecasodium salt hydrate Inhibitor >98.0%
    Phytic acid dodecasodium salt hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium salt hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
  • HY-14268S
    Febuxostat D9 Inhibitor >98.0%
    Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.
  • HY-19657
    Oxypurinol Inhibitor >98.0%
    Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
  • HY-U00288
    Xanthine oxidase-IN-1 Inhibitor
    Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
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