1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase

Xanthine Oxidase

Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.

Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.

Xanthine Oxidase Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-N0196
    Baicalein Inhibitor >98.0%
    Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 mM.
  • HY-14268
    Febuxostat Inhibitor 99.94%
    Febuxostat(TEI 6720;TMX 67 ) is selective xanthine oxidase inhibitor with Ki of 0.6 nM.
  • HY-14874
    Topiroxostat Inhibitor 98.54%
    Topiroxostat(FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM.
  • HY-B0219
    Allopurinol Inhibitor >99.0%
    Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
  • HY-B1135
    Benzbromarone Inhibitor 99.17%
    Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout.
  • HY-19657
    Oxypurinol Inhibitor
    Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
  • HY-N0814
    Phytic acid Inhibitor
    Phytic acid is a major phosphorus storage compound of most seeds and cereal grains.
  • HY-14268S
    Febuxostat D9 Inhibitor >98.0%
    Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.
  • HY-U00288
    Xanthine oxidase-IN-1 Inhibitor
    Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
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