1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Xanthine Oxidase
  3. Oxypurinol

Oxypurinol (Synonyms: Oxipurinol)

Cat. No.: HY-19657 Purity: >98.0%
Handling Instructions

Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.

For research use only. We do not sell to patients.

Oxypurinol Chemical Structure

Oxypurinol Chemical Structure

CAS No. : 2465-59-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Allopurinol is rapidly metabolized (half-life approximately 1 h) to its active metabolite oxypurinol. Oxypurinol is an inhibitor of xanthine oxidoreductase and has a considerably longer elimination half-life (approximately 23 h)[1].

Clinical Trial
Molecular Weight

152.11

Formula

C₅H₄N₄O₂

CAS No.

2465-59-0

SMILES

O=C1C2=C(NN=C2)NC(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (82.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5742 mL 32.8709 mL 65.7419 mL
5 mM 1.3148 mL 6.5742 mL 13.1484 mL
10 mM 0.6574 mL 3.2871 mL 6.5742 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (8.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (8.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (8.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Oxypurinol
Cat. No.:
HY-19657
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