Xanthine
Based on 8 publication(s) in Google Scholar
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation.
For research use only. We do not sell to patients.
- Purity : 98.99%
- CAS No.: 69-89-6
- Formula: C5H4N4O2
- Molecular Weight:152.11
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Xanthine
More- Adv Mater. 2025 Aug;37(34):e2504829. [Abstract]
- Cancer Lett. 2025 Dec 1:634:218069. [Abstract]
- Talanta. 2024 Jan 15:267:125171. [Abstract]
- Colloids Surf B Biointerfaces. 2024 Jun:238:113887. [Abstract]
- Colloids Surf A Physicochem Eng Asp. 2025 Oct 27.
- Cell Biol Int. 2026 Mar;50(3):e70149. [Abstract]
- BMC Neurol. 2023 Dec 16;23(1):444. [Abstract]
- Research Square Preprint. 2022 Feb.
Customer Validation & Images
-
Cell Proliferation/Viability Assay
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
|
Microbial Metabolite |
In Vitro
Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 69-89-6
-
Appearance Solid
-
Molecular Weight 152.11
-
Formula C5H4N4O2
-
Color White to light yellow
-
SMILES
O=C(N1)NC2=C(N=CN2)C1=O
-
Structure Classification
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
-
Journal Impact Factor
-
Most Recent
-
Adv Mater
Nanozyme-Reinforced Hydrogel Spray as a Reactive Oxygen Species-Driven Oxygenator to Accelerate Diabetic Wound Healing. [Abstract]2025 Aug;37(34):e2504829. PMID: 40492891 -
Cancer Lett
2025 Dec 1:634:218069. PMID: 41033606
Xanthine purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Dec 1:634:218069. [Abstract]
Xanthine (500–2000 μM; 120 h) caused PC-9 and H1975 cell death in a dose-dependent manner.
-
Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
Colloids Surf B Biointerfaces
In-situ growth of CeO2 on biofilms: Innovative nanoparticles for photothermal therapy & multi-pronged attack on Alzheimer's disease. [Abstract]2024 Jun:238:113887. PMID: 38581835 -
-
Cell Biol Int
γδTreg/γδTh17 Cell Imbalance Drives Xanthine-Mediated Metabolic Dysfunction in Restraint Stress-Induced Anxiety-Like Behavior. [Abstract]2026 Mar;50(3):e70149. PMID: 41830399 -
BMC Neurol
Integrative analysis of purine metabolites and gut microbiota in patients with neuromyelitis optica spectrum disorders after mycophenolate mofetil treatment. [Abstract]2023 Dec 16;23(1):444. PMID: 38102573 -
Solvent & Solubility
In Vitro:
1M NaOH : 8.33 mg/mL (54.76 mM; ultrasonic and adjust pH to 11 with NaOH)
H2O : 5 mg/mL (32.87 mM; ultrasonic and warming and adjust pH to 10 with 1M NaOH and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Pundir CS, Devi R. Biosensing methods for xanthine determination: a review. Enzyme Microb Technol. 2014;57:55-62. [Content Brief]
[2]. David A. Taylor, et al. Central Nervous SystemStimulants.
[3]. Ashihara H, et al. Xanthine Alkaloids: Occurrence, Biosynthesis, and Function in Plants. Prog Chem Org Nat Prod. 2017;105:1-88. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1M NaOH | 1 mM | 6.5742 mL | 32.8709 mL | 65.7419 mL | 164.3547 mL |
| 5 mM | 1.3148 mL | 6.5742 mL | 13.1484 mL | 32.8709 mL | |
| 10 mM | 0.6574 mL | 3.2871 mL | 6.5742 mL | 16.4355 mL | |
| 15 mM | 0.4383 mL | 2.1914 mL | 4.3828 mL | 10.9570 mL | |
| 20 mM | 0.3287 mL | 1.6435 mL | 3.2871 mL | 8.2177 mL | |
| 25 mM | 0.2630 mL | 1.3148 mL | 2.6297 mL | 6.5742 mL | |
| 30 mM | 0.2191 mL | 1.0957 mL | 2.1914 mL | 5.4785 mL | |
| 1M NaOH | 40 mM | 0.1644 mL | 0.8218 mL | 1.6435 mL | 4.1089 mL |
| 50 mM | 0.1315 mL | 0.6574 mL | 1.3148 mL | 3.2871 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Xanthine Related Classifications
HY-W017389 Related Classifications
Powered by Bioz