1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adenosine Receptor
    Endogenous Metabolite
  3. Inosine

Inosine 

Cat. No.: HY-N0092 Purity: ≥98.0%
Handling Instructions

Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.

For research use only. We do not sell to patients.

Inosine Chemical Structure

Inosine Chemical Structure

CAS No. : 58-63-9

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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10 g USD 65 In-stock
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25 g USD 75 In-stock
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100 g USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

IC50 & Target[1]

Human Endogenous Metabolite

 

A1R

 

A2AR

 

In Vitro

Inosine dose-dependently stimulates cAMP production mediated through the A2AR[2].
Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation[2].
Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male/female C57BL/6 mice[2]
Dosage: 1 mg/kg, 10 mg/kg, 100 mg/kg
Administration: Intraperitoneal injection, 20 min before formalin treatment
Result: Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).
Clinical Trial
Molecular Weight

268.23

Formula

C₁₀H₁₂N₄O₅

CAS No.
SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (93.20 mM; Need ultrasonic)

H2O : 10 mg/mL (37.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7281 mL 18.6407 mL 37.2814 mL
5 mM 0.7456 mL 3.7281 mL 7.4563 mL
10 mM 0.3728 mL 1.8641 mL 3.7281 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 15.56 mg/mL (58.01 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (9.32 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

InosineAdenosine ReceptorEndogenous MetaboliteP1 receptornucleosideadenosinemetabolismhumanmetaboliteneuroprotectiveantinociceptiveantiallodynicantihyperalgesicimmunomodulatoryParkinson'sdiseaseInhibitorinhibitorinhibit

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Product Name:
Inosine
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HY-N0092
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