Adenosine A_2A receptor (A_2AR)

Adenosine A_2A receptor (A_2AR) Related Products (29):

By Type:	Pan (12) Selective (13)
By Effects:	Inhibitors (3) Agonists (2) Antagonists (24)

Cat. No.	Product Name	Effect	Purity

HY-N0092

Inosine	Agonist	99.61%
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors.

HY-19532

ZM241385	Antagonist	99.26%
ZM241385 is a potent, high affinity and selective adenosine A_2a receptor (A_2AR) antagonist with a K_i value of 1.4 nM.

HY-14858

Derenofylline	Antagonist	99.87%
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A₁ receptor antagonist, with K_i values of 1 nM, 200 nM and 398 nM for human A₁, A₃ and A_2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.

HY-148088

M1069	Antagonist	98.04%
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.

HY-103175

PSB36	Antagonist	≥99.0%
PSB36 is a potent and selective antagonist of adenosine A₁ receptor, with K_is 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA₁, hA_2B, rA_2A, hA₃ and rA₃ receptors respectively. PSB36 can be used for the research of hyperalgesia.

HY-120652

A3AR antagonist 3	Antagonist
A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a K_i of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors.

HY-N12422

A2AAR antagonist 2	Antagonist
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research.

HY-158057

A2AR/A2BR antagonist 1	Antagonist
A_2AR/A_2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A_2AR/A_2BR, with the IC₅₀ values of 11.2 nM and 6.4 nM for A_2AR and A_2BR, respectively. A_2AR/A_2BR antagonist 1 promotes T cell-mediated cancer cell death.

HY-103162

ANR94	Antagonist
ANR94 is a potent and selective adenosine A_2A receptor (AA_2AR) antagonist with an K_i of 46 nM for hAA_2AR. ANR94 has the potential for the research of Parkinson's disease.

HY-103174

MRS1334	Antagonist	≥99.0%
MRS1334 is a potent and selective human adenosine A₃ receptor antagonist with K_is of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144064

Adenosine receptor antagonist 2	Antagonist	99.37%
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC₅₀s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.

HY-116800

FR194921	Antagonist	98.10%
FR194921 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with K_i value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity.

HY-147908

Adenosine receptor inhibitor 2	Inhibitor
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A₁/A_2A ARs with higher affinity for the A₁- than the A_2AAR. Adenosine receptor inhibitor 2 has K_i values of 52.2 nM for the A₁AR and 167 nM for the A_2AAR.

HY-147544

A1AR antagonist 5	Antagonist
A1AR antagonist 5 (compound 20) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC₅₀ of 5.83 and a pK_i of 6.11.

HY-147907

Adenosine receptor inhibitor 1	Inhibitor
Adenosine receptor inhibitor 1 is a potent and selective adenosine receptor (AR) inhibitor with K_i values of >1000, 68.5, >1000, >1000 nM for A₁AR, A_2AAR, A_2BAR, A₃AR, respectively. Adenosine receptor inhibitor 1 shows antinociceptive activity, anti-inflammatory effect and peripheral analgesic effect. Adenosine receptor inhibitor 1 has the potential for the research of cancer or neurodegenerative diseases.

HY-105003

ST 1535	Antagonist
ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease.

HY-147543

A1AR antagonist 4	Antagonist
A1AR antagonist 4 (compound 22) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC₅₀ of 5.51 and a pK_i of 6.29.

HY-111295

LAS38096	Antagonist
LAS38096 is a potent, selective, and efficacious A2B Adenosine Receptor antagonist, with a K_i of 17 nM.

HY-151139

LJ-4517	Antagonist
LJ-4517 is a potent A_2AAR antagonist, with a K_i of 18.3 nM. LJ-4517 is potent in displacing the binding of [³H]ZM241385 (HY-19532) at WT A_2AAR. LJ-4517 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103170

LUF5834	Agonist
LUF5834 is a selective A_2B adenosine receptor (A2BR) partial agonist (EC₅₀ = 12 nM). LUF5834 is also a partial A₁/A_2A adenosine receptor agonist (lacking selectivity) with K_i values of 2.6 and 28 nM, respectively.

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