Adenosine receptor inhibitor 2
Based on 1 Customer Validation
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR.
For research use only. We do not sell to patients.
- Purity: 99.08%
- CAS No.: 2550401-76-6
- Formula: C17H20BrN5O2
- Molecular Weight:406.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
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A1AR 52.2 ± 8.5 nM (Ki) |
A2AR 167 ± 22 nM (Ki) |
hA2B >1000 nM (Ki) |
Adenosine A3 receptor >1000 nM (Ki) |
Chemical Information
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CAS No. 2550401-76-6
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Appearance Solid
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Molecular Weight 406.28
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Formula C17H20BrN5O2
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Color White to off-white
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SMILES
O=C(N1CC)N(CC)C2=C(N(C)C(NCC3=CC=CC(Br)=C3)=N2)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (123.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4614 mL | 12.3068 mL | 24.6136 mL | 61.5339 mL |
| 5 mM | 0.4923 mL | 2.4614 mL | 4.9227 mL | 12.3068 mL | |
| 10 mM | 0.2461 mL | 1.2307 mL | 2.4614 mL | 6.1534 mL | |
| 15 mM | 0.1641 mL | 0.8205 mL | 1.6409 mL | 4.1023 mL | |
| 20 mM | 0.1231 mL | 0.6153 mL | 1.2307 mL | 3.0767 mL | |
| 25 mM | 0.0985 mL | 0.4923 mL | 0.9845 mL | 2.4614 mL | |
| 30 mM | 0.0820 mL | 0.4102 mL | 0.8205 mL | 2.0511 mL | |
| 40 mM | 0.0615 mL | 0.3077 mL | 0.6153 mL | 1.5383 mL | |
| 50 mM | 0.0492 mL | 0.2461 mL | 0.4923 mL | 1.2307 mL | |
| 60 mM | 0.0410 mL | 0.2051 mL | 0.4102 mL | 1.0256 mL | |
| 80 mM | 0.0308 mL | 0.1538 mL | 0.3077 mL | 0.7692 mL | |
| 100 mM | 0.0246 mL | 0.1231 mL | 0.2461 mL | 0.6153 mL |
Adenosine receptor inhibitor 2 Related Classifications
HY-147908 Related Classifications
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