1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (83):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc is a potent and selective Gardos channel blocker with IC50 value of 11 nM, and blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.85%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2 receptors, 5-HT2A receptors, potassium channel, sodium channel, with Ki of 363 nM and 8.3 nM for dopamine D2 receptor and serotonin 5-HT2A receptor, respectively.
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production.
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
  • HY-D0143
    Quinine Inhibitor 99.59%
    Quinine is an anti-malaria agent and also a potassium channel inhibitor with an IC50 of 169 μM.
  • HY-104005
    ML335 Activator 99.82%
    ML335 is a selective activator of both TREK-1 and TREK-2.
  • HY-N0221
    Daurisoline Inhibitor 98.02%
    Daurisoline is a hERG inhibitor and also an autophagy blocker.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is a steroid glycoside derivative which affects endothelium relaxation in the aorta.
  • HY-B1140
    Diazoxide Activator 99.76%
    Diazoxide is an ATP-sensitive potassium channel activator ; can be used to treat hyperinsulinism.
  • HY-13519
    TRAM-34 Inhibitor 99.71%
    TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
  • HY-B0604
    4-Aminopyridine Inhibitor 99.97%
    4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.
  • HY-15598
    20-HETE Inhibitor
    20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels.
  • HY-B0401
    Tolbutamide Inhibitor >98.0%
    Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.
  • HY-B0112
    Minoxidil Activator 99.84%
    Minoxidil(U 10858) is an antihypertensive vasodilator medication.
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity.
  • HY-12637
    Hexachlorophene Activator 99.66%
    Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor 99.31%
    Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
  • HY-B0232
    Dofetilide Inhibitor >98.0%
    Dofetilide(Tikosyn) is a class III antiarrhythmic agent.