1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (124):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide is a selective inhibitor of ATP-sensitive K+ channel.
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.
  • HY-15598
    20-HETE Inhibitor
    20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells.
  • HY-100230A
    ML133 hydrochloride Inhibitor 99.89%
    ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
  • HY-112705
    VU0529331 Inhibitor >99.0%
    VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.
  • HY-12882A
    Ifenprodil tartrate Inhibitor
    Ifenprodil tartrate is the atypical N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50 = 0.34 μM). Ifenprodil tartrate inhibits G protein-activated inwardly rectifying K+ channels (GIRK, also known as Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil, which is a clinically used cerebral vasodilator, interacts with several receptors, such as alpha1 adrenergic, N-methyl-D-aspartate, serotonin and sigma receptors.
  • HY-B0604
    4-Aminopyridine Inhibitor 99.97%
    4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel.
  • HY-B0401
    Tolbutamide Inhibitor 99.96%
    Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.
  • HY-B0232
    Dofetilide Inhibitor 98.77%
    Dofetilide(Tikosyn) is a class III antiarrhythmic agent.
  • HY-B1140
    3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide Activator 99.99%
    3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) is an ATP-sensitive potassium channel activator, can be used to treat hyperinsulinism.
  • HY-B0112
    Minoxidil Activator 99.96%
    Minoxidil(U 10858) is an antihypertensive vasodilator medication.
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
  • HY-B1221
    Flufenamic acid Activator 99.92%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels.
  • HY-B1193
    Terfenadine Inhibitor 98.26%
    Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 and induces p73, Noxa.
  • HY-12496
    NS-1619 Activator 99.30%
    NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.
Isoform Specific Products

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