1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (92):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide is a selective inhibitor of ATP-sensitive K+ channel.
  • HY-B0604
    4-Aminopyridine Inhibitor 99.97%
    4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.
  • HY-14290A
    Pinacidil monohydrate >99.0%
    Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
  • HY-110110
    VU0463271 Inhibitor
    VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
  • HY-33350
    Clofilium tosylate Inhibitor
    Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent.
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-B0401
    Tolbutamide Inhibitor 99.96%
    Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.
  • HY-B0232
    Dofetilide Inhibitor >98.0%
    Dofetilide(Tikosyn) is a class III antiarrhythmic agent.
  • HY-B1140
    Diazoxide Activator 99.99%
    Diazoxide is an ATP-sensitive potassium channel activator ; can be used to treat hyperinsulinism.
  • HY-13519
    TRAM-34 Inhibitor 99.71%
    TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel.
  • HY-B0112
    Minoxidil Activator 99.84%
    Minoxidil(U 10858) is an antihypertensive vasodilator medication.
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
  • HY-B1221
    Flufenamic acid Activator 99.92%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels.
  • HY-N0451
    Acacetin Inhibitor 98.43%
    1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.
  • HY-17001
    Flupirtine Maleate Activator 99.97%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
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