1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (87):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2 receptors, 5-HT2A receptors, potassium channel, sodium channel, with Ki of 363 nM and 8.3 nM for dopamine D2 receptor and serotonin 5-HT2A receptor, respectively.
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc is a potent and selective Gardos channel blocker with IC50 value of 11 nM, and blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
  • HY-15598
    20-HETE Inhibitor
    20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels.
  • HY-P1275
    Tertiapin-Q Inhibitor
    Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1).
  • HY-100238
    Antihistamine-1 Inhibitor
    Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
  • HY-100321
    MCHr1 antagonist 2 Inhibitor
    MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHr1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-B1140
    Diazoxide Activator 99.76%
    Diazoxide is an ATP-sensitive potassium channel activator ; can be used to treat hyperinsulinism.
  • HY-13519
    TRAM-34 Inhibitor 99.71%
    TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).
  • HY-B0112
    Minoxidil Activator 99.84%
    Minoxidil(U 10858) is an antihypertensive vasodilator medication.
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
  • HY-B0401
    Tolbutamide Inhibitor >98.0%
    Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel.
  • HY-B0232
    Dofetilide Inhibitor >98.0%
    Dofetilide(Tikosyn) is a class III antiarrhythmic agent.
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor 99.31%
    Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).
  • HY-17001
    Flupirtine Maleate Activator 99.97%
    Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
  • HY-14183
    Vernakalant Hydrochloride Inhibitor 99.33%
    Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
Isoform Specific Products

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