1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Tannic acid

Tannic acid 

Cat. No.: HY-B2136
Handling Instructions

Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

For research use only. We do not sell to patients.

Tannic acid Chemical Structure

Tannic acid Chemical Structure

CAS No. : 1401-55-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 84 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

IC50 & Target

IC50: 3.4 μM (hERG channel)[1]

In Vivo

During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2].

Clinical Trial
Molecular Weight

1701.20

Formula

C₇₆H₅₂O₄₆

CAS No.

1401-55-4

SMILES

O=C(C1=CC(OC(C2=CC(O)=C(O)C(O)=C2)=O)=C(O)C(O)=C1)OC3[[email protected]](OC(C4=CC(OC(C5=CC(O)=C(O)C(O)=C5)=O)=C(O)C(O)=C4)=O)[[email protected]@H](OC(C6=CC(OC(C7=CC(O)=C(O)C(O)=C7)=O)=C(O)C(O)=C6)=O)[[email protected]](OC(C8=CC(OC(C9=CC(O)=C(O)C(O)=C9)=O)=C(O)C(O)=C8)=O)[[email protected]@H](COC(C%10=CC(OC(C%11=CC(O)=C(O)C(O)=C%11)=O)=C(O)C(O)=C%10)=O)O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (58.78 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (58.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5878 mL 2.9391 mL 5.8782 mL
5 mM 0.1176 mL 0.5878 mL 1.1756 mL
10 mM 0.0588 mL 0.2939 mL 0.5878 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

Specific pathogen-free female 6 weeks old mice are used. The animals are maintained in a controlled room (temperature 23±2 °C, humidity 55±15%, 12 h light cycle). After 1 week, the mice arer andomly divided into 3 groups, untreated group-receive vehicle (distill water) (Normal, n=5); DfE cream treated mice (100 mg/mouse) is divided into two groups and each receives vehicle (distill water) (AD, n=5) or Tannic acid (80 mg/kg/day, per oral) (AD+Tannic acid, n=5) and are allowed free access to drinking water and standard laboratory diet[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Tannic acidPotassium ChannelKcsAInhibitorinhibitorinhibit

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