1. Signaling Pathways
  2. GPCR/G Protein
  3. Succinate Receptor 1

Succinate Receptor 1


The succinate receptor (SUCNR1, also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. The Succinate receptor was identified as being activated by physiological levels of the Kreb's cycle intermediate succinate and other dicarboxylic acids such as maleate. It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina, and kidney. In these tissues, this receptor and its ligand succinate have recently emerged as novel mediators in local stress situations, including ischemia, hypoxia, toxicity, and hyperglycemia. Amongst others, the succinate receptor is involved in recruitment of immune cells to transplanted tissues. Moreover, it was shown to play a key role in the development of diabetic retinopathy. However, most prominently, the role of locally increased succinate levels and succinate receptor activation in the kidney, stimulating the systemic and local renin–angiotensin system, starts to unfold: the succinate receptor is a key mediator in the development of hypertension and possibly fibrosis in diabetes mellitus and metabolic syndrome.

Succinate Receptor 1 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-130246
    NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
  • HY-125791
    cis-Epoxysuccinic acid
    Agonist 99.00%
    cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system.
  • HY-126217
    hGPR91 antagonist 1
    hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC50 of 7 nM for human GPR91.
  • HY-145919
    hGPR91 antagonist 3
    hGPR91 antagonist 3 (Compound 5g) is a potent and orally active GPR91 antagonist with IC50 of 35 nM and 135 nM, for human GPR91 and rat GPR91, respectively.
  • HY-154946
    SUCNR1-IN-1 (Compound 20) is a SUCNR1 inhibitor (IC50: 88 nM for hSUCNR1). SUCNR1-IN-1 can be used for research of rheumatoid arthritis, liver fibrosis, or obesity.