1. GPCR/G Protein
  2. Succinate Receptor 1
  3. cis-Epoxysuccinic acid

cis-Epoxysuccinic acid 

Cat. No.: HY-125791
Handling Instructions

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system.

For research use only. We do not sell to patients.

cis-Epoxysuccinic acid Chemical Structure

cis-Epoxysuccinic acid Chemical Structure

CAS No. : 16533-72-5

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Description

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].

In Vitro

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 1, 10 and 100 μM
Incubation Time: 10 min
Result: Inhibited cAMP levels with an EC50 value of 2.7 µM.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0.1 μM-100 mM
Incubation Time: 1 hour
Result: Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]i mobilization with EC50 values of 42, 74 and 191 µM, respectively.
In Vivo

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once
Result: Showed in vivo activity and increased blood pressure after injection.
Molecular Weight

132.07

Formula

C4H4O5

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Please store the product under the recommended conditions in the Certificate of Analysis.

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cis-Epoxysuccinic acid
Cat. No.:
HY-125791
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