cis-Epoxysuccinic acid

Name: cis-Epoxysuccinic acid
Brand: MedChemExpress
SKU: HY-125791
Rating: 5.0 (3 reviews)

Cat. No.: HY-125791 Pureza: 98.0%: Ficha de datos
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cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC₅₀ value of 2.7 μM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system.

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cis-Epoxysuccinic acid Estructura química

No. CAS : 16533-72-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
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50 g	Obtener un presupuesto

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Revisión del cliente

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE cis-Epoxysuccinic acid

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

In Vitro

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells^[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HEK293 cells
Concentration:	1, 10 and 100 μM
Incubation Time:	10 min
Result:	Inhibited cAMP levels with an EC₅₀ value of 2.7 µM.

Cell Viability Assay^[1]

Cell Line:	HEK293 cells
Concentration:	0.1 μM-100 mM
Incubation Time:	1 hour
Result:	Induced the Gq pathway, recruited arrestin 3 and elicited [Ca²⁺]_i mobilization with EC₅₀ values of 42, 74 and 191 µM, respectively.

In Vivo

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once
Result:	Showed in vivo activity and increased blood pressure after injection.

Peso molecular

132.07

Fòrmula

C₄H₄O₅

No. CAS

16533-72-5

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1O[C@@H]1C(O)=O)O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 250 mg/mL (1892.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5717 mL	37.8587 mL	75.7174 mL
5 mM	1.5143 mL	7.5717 mL	15.1435 mL
10 mM	0.7572 mL	3.7859 mL	7.5717 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.0%

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Ficha de datos (273 KB) SDS (393 KB)

COA (246 KB) HNMR (227 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Geubelle P, et al. Identification and pharmacological characterization of succinate receptor agonists. Br J Pharmacol. 2017 May;174(9):796-808. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.5717 mL	37.8587 mL	75.7174 mL	189.2935 mL
	5 mM	1.5143 mL	7.5717 mL	15.1435 mL	37.8587 mL
	10 mM	0.7572 mL	3.7859 mL	7.5717 mL	18.9294 mL
	15 mM	0.5048 mL	2.5239 mL	5.0478 mL	12.6196 mL
	20 mM	0.3786 mL	1.8929 mL	3.7859 mL	9.4647 mL
	25 mM	0.3029 mL	1.5143 mL	3.0287 mL	7.5717 mL
	30 mM	0.2524 mL	1.2620 mL	2.5239 mL	6.3098 mL
	40 mM	0.1893 mL	0.9465 mL	1.8929 mL	4.7323 mL
	50 mM	0.1514 mL	0.7572 mL	1.5143 mL	3.7859 mL
	60 mM	0.1262 mL	0.6310 mL	1.2620 mL	3.1549 mL
	80 mM	0.0946 mL	0.4732 mL	0.9465 mL	2.3662 mL
	100 mM	0.0757 mL	0.3786 mL	0.7572 mL	1.8929 mL