1. GPCR/G Protein
  2. Succinate Receptor 1
  3. cis-Epoxysuccinic acid

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system.

For research use only. We do not sell to patients.

cis-Epoxysuccinic acid Chemical Structure

cis-Epoxysuccinic acid Chemical Structure

CAS No. : 16533-72-5

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE cis-Epoxysuccinic acid

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Description

cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].

In Vitro

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 1, 10 and 100 μM
Incubation Time: 10 min
Result: Inhibited cAMP levels with an EC50 value of 2.7 µM.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0.1 μM-100 mM
Incubation Time: 1 hour
Result: Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]i mobilization with EC50 values of 42, 74 and 191 µM, respectively.
In Vivo

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once
Result: Showed in vivo activity and increased blood pressure after injection.
Molecular Weight

132.07

Formula

C4H4O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1O[C@@H]1C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (1892.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5717 mL 37.8587 mL 75.7174 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.5717 mL 37.8587 mL 75.7174 mL 189.2935 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL 37.8587 mL
10 mM 0.7572 mL 3.7859 mL 7.5717 mL 18.9294 mL
15 mM 0.5048 mL 2.5239 mL 5.0478 mL 12.6196 mL
20 mM 0.3786 mL 1.8929 mL 3.7859 mL 9.4647 mL
25 mM 0.3029 mL 1.5143 mL 3.0287 mL 7.5717 mL
30 mM 0.2524 mL 1.2620 mL 2.5239 mL 6.3098 mL
40 mM 0.1893 mL 0.9465 mL 1.8929 mL 4.7323 mL
50 mM 0.1514 mL 0.7572 mL 1.5143 mL 3.7859 mL
60 mM 0.1262 mL 0.6310 mL 1.2620 mL 3.1549 mL
80 mM 0.0946 mL 0.4732 mL 0.9465 mL 2.3662 mL
100 mM 0.0757 mL 0.3786 mL 0.7572 mL 1.8929 mL
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cis-Epoxysuccinic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
cis-Epoxysuccinic acid
Cat. No.:
HY-125791
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