hGPR91 antagonist 1

Name: hGPR91 antagonist 1
Brand: MedChemExpress
SKU: HY-126217
Rating: 4.5 (1 reviews)

Cat. No.: HY-126217 Purity: 98.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC₅₀ of 7 nM for human GPR91.

For research use only. We do not sell to patients.

hGPR91 antagonist 1 Chemical Structure

CAS No. : 1314796-00-3

Size Price Stock Quantity

Solid + Solvent

10 mM * 1 mL in DMSO
ready for reconstitution
USD 286 In-stock

Estimated Time of Arrival: December 31

Solution

10 mM * 1 mL in DMSO USD 286 In-stock

Estimated Time of Arrival: December 31

Solid

5 mg USD 260 In-stock

Estimated Time of Arrival: December 31

10 mg USD 380 In-stock

Estimated Time of Arrival: December 31

25 mg USD 800 In-stock

Estimated Time of Arrival: December 31

50 mg USD 1280 In-stock

Estimated Time of Arrival: December 31

100 mg USD 2100 In-stock

Estimated Time of Arrival: December 31

200 mg Get quote

500 mg Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

hGPR91 antagonist 1 Related Antibodies

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Purity & Documentation

References

Customer Review

Description

hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC₅₀ of 7 nM for human GPR91^[1].

IC₅₀ & Target
IC50: 7 μM (HGPR91)^[1]

In Vivo

HGPR91 antagonist 1 (Compound 4c) leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats^[1]

Dosage: 100 mg/kg

Administration: I.p.; 2 and 4 hours

Result: Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours.

Molecular Weight
529.53

Formula
C₃₁H₂₃F₄N₃O

CAS No.
1314796-00-3

Appearance

Solid

Color

White to off-white

SMILES
O=C(N[C@@H](C)C1=CC=C(C2=CC=C(F)C(C(F)(F)F)=C2)C=C1)CC3=CC=C(C4=NC5=NC=CC=C5C=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility
In Vitro:

DMSO : ≥ 125 mg/mL (236.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 1.8885 mL 9.4423 mL 18.8847 mL

5 mM 0.3777 mL 1.8885 mL 3.7769 mL

10 mM 0.1888 mL 0.9442 mL 1.8885 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
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(per animal)
g

Dosing volume
(per animal)
μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.71%
Select Batch:

Data Sheet (274 KB) SDS (251 KB)
COA (251 KB) HNMR (305 KB) LCMS (264 KB)
Handling Instructions (2659 KB)

References

[1]. Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. [Content Brief]

[1]. Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 1.8885 mL 9.4423 mL 18.8847 mL 47.2117 mL

5 mM 0.3777 mL 1.8885 mL 3.7769 mL 9.4423 mL

10 mM 0.1888 mL 0.9442 mL 1.8885 mL 4.7212 mL

15 mM 0.1259 mL 0.6295 mL 1.2590 mL 3.1474 mL

20 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3606 mL

25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8885 mL

30 mM 0.0629 mL 0.3147 mL 0.6295 mL 1.5737 mL

40 mM 0.0472 mL 0.2361 mL 0.4721 mL 1.1803 mL

50 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL

60 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7869 mL

80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5901 mL

100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4721 mL

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Remarks

hGPR91 antagonist 1 Related Classifications

GPCR/G Protein

Succinate Receptor 1

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hGPR91 antagonist 11314796-00-3Succinate Receptor 1SUCNR1GPR91Inhibitorinhibitorinhibit

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Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 286	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 286	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

DMSO	1 mM	1.8885 mL	9.4423 mL	18.8847 mL	47.2117 mL
	5 mM	0.3777 mL	1.8885 mL	3.7769 mL	9.4423 mL
	10 mM	0.1888 mL	0.9442 mL	1.8885 mL	4.7212 mL
	15 mM	0.1259 mL	0.6295 mL	1.2590 mL	3.1474 mL
	20 mM	0.0944 mL	0.4721 mL	0.9442 mL	2.3606 mL
	25 mM	0.0755 mL	0.3777 mL	0.7554 mL	1.8885 mL
	30 mM	0.0629 mL	0.3147 mL	0.6295 mL	1.5737 mL
	40 mM	0.0472 mL	0.2361 mL	0.4721 mL	1.1803 mL
	50 mM	0.0378 mL	0.1888 mL	0.3777 mL	0.9442 mL
	60 mM	0.0315 mL	0.1574 mL	0.3147 mL	0.7869 mL
	80 mM	0.0236 mL	0.1180 mL	0.2361 mL	0.5901 mL
	100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.4721 mL

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hGPR91 antagonist 1

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