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hGPR91 antagonist 1 

Cat. No.: HY-126217
Handling Instructions

HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM.

For research use only. We do not sell to patients.

hGPR91 antagonist 1 Chemical Structure

hGPR91 antagonist 1 Chemical Structure

CAS No. : 1314796-00-3

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Description

HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM[1].

IC50 & Target

IC50: 7 μM (HGPR91)[1]

In Vivo

HGPR91 antagonist 1 leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM[1].

Animal Model: Wistar rats[1]
Dosage: 100 mg/kg
Administration: I.p.; 2 and 4 hours
Result: Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours.
Molecular Weight

529.53

Formula

C₃₁H₂₃F₄N₃O

CAS No.

1314796-00-3

SMILES

O=C(N[[email protected]@H](C)C1=CC=C(C2=CC=C(F)C(C(F)(F)F)=C2)C=C1)CC3=CC=C(C4=NC5=NC=CC=C5C=C4)C=C3

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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hGPR91 antagonist 1
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HY-126217
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