hGPR91 antagonist 1
Based on 3 publication(s) in Google Scholar
hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC50 of 7 nM for human GPR91.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 1314796-00-3
- Formula: C31H23F4N3O
- Molecular Weight:529.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) hGPR91 antagonist 1
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Biological Activity
IC50: 7 μM (HGPR91)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
>30 μM
Compound: 4c
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Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay
Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay
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[PMID: 21571530] |
| CHO-K1 | IC50 |
7 nM
Compound: 4c
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Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay
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[PMID: 21571530] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats[1]
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Dosage:100 mg/kg
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Administration:I.p.; 2 and 4 hours
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Result:Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours.
Chemical Information
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CAS No. 1314796-00-3
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Appearance Solid
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Molecular Weight 529.53
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Formula C31H23F4N3O
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Color White to off-white
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SMILES
O=C(N[C@@H](C)C1=CC=C(C2=CC=C(F)C(C(F)(F)F)=C2)C=C1)CC3=CC=C(C4=NC5=NC=CC=C5C=C4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Inflammation
SUCNR1 Deficiency Alleviates Liver Ischemia-Reperfusion Injury by Regulating Kupffer Cell Activation and Polarization Through the ERK/NF-κB Pathway in Mice. [Abstract]2025 Mar 19. PMID: 40106070 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
Solvent & Solubility
DMSO : ≥ 125 mg/mL (236.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8885 mL | 9.4423 mL | 18.8847 mL | 47.2117 mL |
| 5 mM | 0.3777 mL | 1.8885 mL | 3.7769 mL | 9.4423 mL | |
| 10 mM | 0.1888 mL | 0.9442 mL | 1.8885 mL | 4.7212 mL | |
| 15 mM | 0.1259 mL | 0.6295 mL | 1.2590 mL | 3.1474 mL | |
| 20 mM | 0.0944 mL | 0.4721 mL | 0.9442 mL | 2.3606 mL | |
| 25 mM | 0.0755 mL | 0.3777 mL | 0.7554 mL | 1.8885 mL | |
| 30 mM | 0.0629 mL | 0.3147 mL | 0.6295 mL | 1.5737 mL | |
| 40 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 1.1803 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3777 mL | 0.9442 mL | |
| 60 mM | 0.0315 mL | 0.1574 mL | 0.3147 mL | 0.7869 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2361 mL | 0.5901 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4721 mL |
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