TSH Receptor
Pituitary control of the thyroid funnels through a single Class A GPCR, the TSH receptor (TSHR). Like FSHR, it carries a large extracellular leucine-rich repeat domain that captures the glycoprotein hormone thyroid-stimulating hormone. In thyroid follicular cells, TSH binding activates Gs and the cAMP/PKA pathway, stimulating glandular growth, iodide uptake and synthesis of thyroxine and triiodothyronine. TSHR is famously the target of stimulating autoantibodies in Graves' disease, the commonest cause of hyperthyroidism, while gain-of-function germline mutations cause familial non-autoimmune hyperthyroidism. Recombinant human TSH is used clinically in the follow-up of differentiated thyroid cancer, and small-molecule allosteric modulators of TSHR are under active investigation.
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TSH Receptor Recombinant Proteins (2)
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Inhibitors & Agonists (24)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
