2. Enzymes
  3. Tissue Dissociation Enzyme

Tissue Dissociation Enzyme

Tissue dissociating enzymes can remove tissue, including trypsin, collagenase series, dispase, thermolysin, etc.

Tissue dissociating enzymes are mainly used for:

• Dissociating tissues and digesting cells

Tissue Dissociation Enzyme (48):

Cat. No. Product Name CAS No.  
  • HY-E70005D
    Collagenase IV, Clostridium histolytica 9001-12-1  
    Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.
  • HY-E70005B
    Collagenase, Type II 9001-12-1  
    Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann.
  • HY-E70005A
    Collagenase, Type I 9001-12-1  
    Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan.
  • HY-131577
    Neutral protease, Paenibacillus polymyxa 42613-33-2  
    Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum.
  • HY-O0004
    Collagenase I, from Clostridium histolyticum 9001-12-1  
    Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.
  • HY-E71003
    Lysozyme Biotin-Caproyl  
    Lysozyme Biotin-Caproyl against immobilized avidin >95%. Contains approx. two moles biotin to one mole of lysozyme.
  • HY-P1748A
    Thermolysin, Geobacillus stearothermophilus  
    Thermolysin (Geobacillus stearothermophilus (EC 3.4.24.27)) is a thermostable neutral metalloproteinase. It requires one zinc ion to maintain enzyme activity and four calcium ions to maintain structural stability. Thermolysin (Geobacillus stearothermophilus (EC 3.4.24.27) specifically catalyzes the hydrolysis of peptide bonds containing hydrophobic amino acids.
  • HY-P2988H
    Neuraminidase,Vibrio cholerae  
    Neuraminidase,Vibrio cholerae (EC 3.2.1.18) is a glycoside hydrolase enzyme that cleave the glycosidic linkages of neuraminic acids.
  • HY-E70005H
    Collagenase, Type VIII 9001-12-1  
    Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis.
  • HY-E70005C
    Collagenase, Type III 9001-12-1  
    Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin
  • HY-126386
    Pectinase, aspergillus niger 9032-75-1  
    Pectinase (EC 3.2.1.15) is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process.
  • HY-E70306
    Zymolyase, Arthrobacter luteus  
    Zymolyase, Arthrobacter luteus, is a zymolyase mainly found in Arthrobacter luteus. Enzyme, an enzyme with beta-1,3 glucanase activity, removes the electron-dense outer layer of the Plasmodium karinii cell wall, exposing an electron-lucent layer.
  • HY-E70005J
    Collagenase, Type VII 9001-12-1  
    Collagenase, Type VII (EC 3.4.24.3) is a collagenase that can be used to induce thalamic hemorrhage.
  • HY-E70005I
    Collagenase, Type VI 9001-12-1  
    Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes.
  • HY-E70130
    Snailase, Snail gastrointestinal 158736-45-9  
    Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc.
  • HY-E70005N
    Collagenase (Type D, animal free) 9001-12-1  
    Collagenase (Type D, animal free) does not contain animal-related components, and has collagenase and secondary protease activities similar to type 1 and type 2 collagenase. The activity of Collagenase (Type D, animal free) is higher than that of Collagenase (Type A, animal free).
  • HY-108903
    Hyaluronidase (human recombinant) 37326-33-3  
    Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media.
  • HY-108903A
    Hyaluronidase, Ovine testes 37326-33-3  
    Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases.
  • HY-B2220A
    Cellulase R-10 from Trichoderma Vride 9012-54-8  
    Cellulase R-10 from Trichoderma Vride is an enzyme mixture that includes cellulase, hemicellulase, pectinase and protease, etc. Cellulase R-10 from Trichoderma Vride can act on the 1,4-β-D-glucosidic bonds in cellulose, catalyzing the hydrolysis of cellulose molecules and generating cellulose oligosaccharides, cellulose di-saccharides and glucose. Cellulase R-10 from Trichoderma Vride can be used in combination with lyase R-10 to break down the cell walls of plants, preparing protoplasts. Cellulase R-10 from Trichoderma Vride is widely applied in plant cell hybridization research.
  • HY-P1068
    Lysozyme 9001-63-2  
    Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages.