42613-33-2
42613-33-2
Chemical Structure
Neutral protease, Paenibacillus polymyxa
Synonym(s): Dispase II, Dispase
- CAS No.: 42613-33-2
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Neutral protease, Paenibacillus polymyxa]
Biological Activity: Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum[1][2].
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Neutral protease, Paenibacillus polymyxa | Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum. | |||||||||||||||||||||
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Neutral protease I | Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin. | |||||||||||||||||||||
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References
- [1]. Stenn KS, et al. Dispase, a neutral protease from Bacillus polymyxa, is a powerful fibronectinase and type IV collagenase. J Invest Dermatol. 1989 Aug;93(2):287-90. [Content Brief]
- [2]. Calvo B, et al. Dissociation of neonatal and adult mice brain for simultaneous analysis of microglia, astrocytes and infiltrating lymphocytes by flow cytometry. IBRO Rep. 2020 Jan 13;8:36-47. [Content Brief]
