GPR39
GPR39 is classified as a class A orphans GPCR. Preliminary evidence pointed to Zn2+ as an endogenous ligand. There is evidence suggesting that GPR39 is a receptor for bile acids, especially for 3-O-sulfated lithocholic acids, and that GPR39 is the membrane receptor for taurolithocholic acid 3-sulfate (TLCAS) in pancreatic acinar cells.
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GPR39 Related Products (9)
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Lithocholic acid 3-sulfate disodium
0 ImagesSynonyms: Sulfolithocholic acid disodium; LCAS disodiumLithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 μM and 0.97 μM in the presence of Zn2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases. -
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TC-G-1008
0 ImagesSynonyms: GPR39-C3TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. -
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Taurolithocholic acid 3-sulfate disodium
0 ImagesSynonyms: 3-Sulfotaurolithocholic acid disodiumTaurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6 and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease. -
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TM-N1324
0 ImagesTM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. -
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Glycolithocholic acid 3-sulfate disodium
0 ImagesSynonyms: Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodiumGlycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease. -
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TMN-OMe
0 ImagesCat. No.: HY-182367TMN-OMe is a blood-brain barrier-permeable GPR39 agonist and a radiotracer for positron emission tomography (PET). TMN-OMe activates GPR39 by recruiting β-arrestin, exhibits highly selective binding ability in the mouse brain, and enables quantitative analysis of GPR39 at the in vivo level. TMN-OMe shows specific uptake in GPR39 knockout mice, Alzheimer's disease model (APP/PS1) mice, and blocking experiments. TMN-OMe facilitates in-depth exploration of changes in GPR39-related mechanisms in neurological diseases and is widely used in Alzheimer's disease research. -
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- Obestatin(human) TFA
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TM-N1324 (Standard)
0 ImagesCat. No.: HY-108699RCAS No.: 1144477-35-9TM-N1324 (Standard) is the analytical standard of TM-N1324 (HY-108699). This product is intended for research and analytical applications. TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. -
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TC-G-1008 (Standard)
0 ImagesCat. No.: HY-103007RCAS No.: 1621175-65-2Synonyms: GPR39-C3 (Standard) -
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