64936-83-0
Chemical Structure
Taurolithocholic acid 3-sulfate disodium
Synonym(s): 3-Sulfotaurolithocholic acid disodium
- CAS No.: 64936-83-0
- Formula:C26H43NNa2O8S2
- Molecular Weight:607.73
IUPAC Name: sodium (3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-5-oxo-5-((2-sulfonatoethyl)amino)pentan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl sulfate
InChIKey: YHTVOGLKSGJIDL-RLHFEMFKSA-L
SMILES: C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Biological Activity: Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6 and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Taurolithocholic acid 3-sulfate disodium | 99.9% | Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6 and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease. | ||||||||||||||||||||
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Taurolithocholic Acid-3-Sulfate-d4 disodium | Taurolithocholic Acid-3-Sulfate-d4 （disodium salt） is the deuterium labeled Taurolithocholic Acid-3-Sulfate. | |||||||||||||||||||||
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