1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Taurolithocholic acid sodium salt

Taurolithocholic acid sodium salt 

Cat. No.: HY-113308A
Handling Instructions

Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist.

For research use only. We do not sell to patients.

Taurolithocholic acid sodium salt Chemical Structure

Taurolithocholic acid sodium salt Chemical Structure

CAS No. : 6042-32-6

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Description

Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

In Vitro

Taurolithocholic acid (TLCA) at low concentrations (5 µM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%[1].
TLCA (10 µM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

505.69

Formula

C₂₆H₄₄NNaO₅S

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Taurolithocholic acidCalcium ChannelCa2+ channelsCa channelsCa2+TLCAPKCPI3KInhibitorinhibitorinhibit

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Taurolithocholic acid sodium salt
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