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SBE-β-CD (Synonyms: Sulfobutylether-β-Cyclodextrin)

Cat. No.: HY-17031 Purity: >98.0%
Handling Instructions

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative, it is an excipient or a formulating agent used to increase the solubility of poorly soluble drugs.

For research use only. We do not sell to patients.

SBE-β-CD Chemical Structure

SBE-β-CD Chemical Structure

CAS No. : 182410-00-0

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  • Biological Activity

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Description

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative, it is an excipient or a formulating agent used to increase the solubility of poorly soluble drugs.

In Vitro

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1].

In Vivo

SBE-β-CD is a derivatized form of β-cyclodextrin that has been developed as a safe and effective solubilizing agent for drugs being administered by parenteral and other routes (including oral). SBE-β-CD is a cyclic carbohydrate comprised of seven glucose molecules; the resulting truncated cone-like structure being further derivatized with an average of seven sulfobutyl ether groups[2]. The calorimetric data for the Compound 1/SBE-β-CD complex indicates an extremely strong interaction, with an association constant of 2.3±(0.2)×106M-1 at 25°C and 1.6±(0.2)×106M-1 at 37°C[3]. SBE-β-CD alone evokes a mild cardio-depressant effect independent of cocaine treatment (p=0.0001 compared to baseline) but attenuates further cocaine-induced decreases in RPP, dP/dtmax, and dP/dtmaxabs at high cocaine concentrations. No significant effect is seen on line pressure SBE-β-CD alleviates the most pronounced cardiac depression for RPP, dP/dtmax, and dP/dtmaxabs. This differential effect of SBE-β-CD at low and high concentrations produces an interaction effect in the two-way ANOVA for RPP (p<0.0001), dP/dtmax (p=0.0001), and dP/dtmaxabs (p=0.0015), and prevents any overall treatment effect. Infusing SBE-β-CD also attenuates the cardiac depression associated with cocaethylene toxicity for RPP and dP/dtmax. No differences are observed between ethanol-treated controls and cocaethylene plus SBE-β-CD groups[4].

Solvent & Solubility
In Vitro: 

H2O : ≥ 155 mg/mL

DMSO : 5.625 mg/mL (Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Animal Administration
[3]

Rats[3]
A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.

182410-00-0

SMILES

[R]O[[email protected]@H]1[[email protected]](O[R])[[email protected]](O[[email protected]@H]2[[email protected]](O[R])C(O[R])[[email protected]](O3)[[email protected]@H](CO[R])O2)[[email protected]@H](CO[R])O[[email protected]@H]1O[[email protected]]4[[email protected]](O[R])[[email protected]@H](O[R])[[email protected]@H](O[[email protected]]5[[email protected]](O[R])[[email protected]@H](O[R])[[email protected]@H](O[[email protected]@H]6C(O[R])[[email protected]](O[R])[[email protected]](O[[email protected]@H]7[[email protected]@H](O[R])[[email protected]](O[R])[[email protected]](O[[email protected]@H]8[[email protected]@H](O[R])[[email protected]](O[R])[[email protected]]3O[[email protected]]8CO[R])O[[email protected]]7CO[R])O[[email protected]]6CO[R])O[[email protected]@H]5CO[R])O[[email protected]@H]4CO[R].[R= H 21-m or C4H8SO3-Na+ m , m=6.0-7.1]

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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SBE-β-CD
Cat. No.:
HY-17031
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SBE-β-CD

Cat. No.: HY-17031