1. Signaling Pathways
  2. PROTAC
  3. ATTEC

ATTEC

Autophagosome-tethering compound (ATTEC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. ATTEC degrades target proteins by molecular glue mechanism, and its molecular weight is smaller than AUTAC. ATTEC shorten the distance between LC3 receptor and target protein and then the target protein was phagocytosed and transferred into lysosomal for degradation.

ATTEC Related Products (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130259
    LC3-mHTT-IN-AN2 7758-73-8
    LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
    LC3-mHTT-IN-AN2
  • HY-130258
    LC3-mHTT-IN-AN1 486443-73-6
    LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
    LC3-mHTT-IN-AN1
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