PCSK9 autophagic degrader 2
Based on 1 publication(s) in Google Scholar
PCSK9 autophagic degrader 2 (W6) is a PCSK9 targeted autophagosome, with an DC50 of 20.6 nM. PCSK9 autophagic degrader 2 (W6) demonstrates comparable antiatherosclerosis effect and exhibits a KD of 2.5 μM for LC3B (Pink: PCSK9 ligand HY-176044; Blue: LC3B ligand HY-176045; Black: linker HY-141373).
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- CAS No.: 2974497-11-3
- Formula: C39H41Br2IN4O8S
- Molecular Weight:1012.54
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Chemical Information
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CAS No. 2974497-11-3
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Molecular Weight 1012.54
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Formula C39H41Br2IN4O8S
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SMILES
O=C(NC1=NC=CS1)CC2(C)NCCC3=C2C=C(OCCOCCOCCOCCN4C(/C(C5=C4C=CC(I)=C5)=C/C6=CC(Br)=C(O)C(Br)=C6)=O)C(OC)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. [Abstract]2025 Apr 24;68(8):8190-8207. PMID: 40226893
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCSK9 autophagic degrader 2 Related Classifications
HY-176043 Related Classifications
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