saRNAs
RNA activation (RNAa) is a process mediated by RNAs to enhance gene expression. This pathway is mediated by a small activating RNA (saRNA). The saRNA is a class of noncoding RNA composed with a 21-nucleotide dsRNA with 2-nucleotide overhangs at both ends. Indeed, saRNA has an identical structure and chemical components to a small interfering RNA (siRNA) despite their completely opposite biological functions. The key difference between saRNA and siRNA lies at the mechanism of action. Cytosolic saRNA is specifically loaded to an AGO2 protein but not the other AGO variants, unlike siRNA which can bind to AGO1-4 for activity.
MTL-CEBPA sodium
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RNA (mGmCGmGUCAUUmGUCAmCUGGUCmUmU); complex with RNA (GACCAGUGACAAUGACCGCmUmU) (1:1) (sodium)
Art. -Nr.: HY-132607A
Synonyms: CEBPA-51 sodium
- Molecular Weight: 13464.27 (free acid)
MTL-CEBPA
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RNA (mGmCGmGUCAUUmGUCAmCUGGUCmUmU); complex with RNA (GACCAGUGACAAUGACCGCmUmU) (1:1)
Art. -Nr.: HY-132607
CAS. Nr.: 2862057-05-2
Synonyms: CEBPA-51
- Molecular Weight: 13464.27
MTL-CEPBA is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEPBA has anti-inflammatory and anti-cancer activity.
dsP53-285 saRNA
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dsP53-285 saRNA
Art. -Nr.: HY-177375
dsP53-285 saRNA is a small activating RNA (saRNA) that readily activates wild-type p53 expression by targeting its promoter. dsP53-285 saRNA suppresses bladder cancer cells growth and metastasis.
