1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glucokinase

Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-N2341
    Palmitelaidic Acid Activator >99.0%
    Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
  • HY-10595
    Ro 28-1675 Activator 99.41%
    Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.
  • HY-100221
    AM-2394 Activator 98.71%
    AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
  • HY-12411
    AMG-3969 Modulator 99.63%
    AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.
  • HY-13529
    LY2608204 Activator 98.18%
    LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.
  • HY-101788
    Glucokinase activator 1 Activator
    Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
  • HY-100181
    PF-04991532 Activator
    PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
  • HY-U00411
    PSN-GK1 Activator
    PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.
Isoform Specific Products

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