1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. Cadisegliatin

Cadisegliatin (Synonyms: TTP-399)

Cat. No.: HY-147254
Handling Instructions

Cadisegliatin (TTP-399) is a potential liver-selective glucokinase (GK) activator for type 2 diabetes and has antihyperglycaemic activity.

For research use only. We do not sell to patients.

Cadisegliatin Chemical Structure

Cadisegliatin Chemical Structure

CAS No. : 859525-02-3

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Description

Cadisegliatin (TTP-399) is a potential liver-selective glucokinase (GK) activator for type 2 diabetes and has antihyperglycaemic activity[1][2].

In Vitro

Cadisegliatin (TTP-399) increases glucose metabolism in rat hepatocytes, the EC50 values of lactate and glycogen in 15 nM glucose are 2.39 μM and 2.64 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TTP399 (200 mg/kg, per os, p.o.) has no effect on plasma glucose and insulin in fasted rats[2].
TTP399 (75 or 150 mg/kg, per day, for 4 weeks) improves glucose homeostasis in ob/ob mouse model[2].
TTP399 (50 mg/kg, per day, for 13 weeks) is effective in reducing plasma glucose during an oral glucose tolerance test (OGTT) in minipigs model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nondiabetic fasted rats[2]
Dosage: 200 mg/kg
Administration: 200 mg/kg, per os (p.o.)
Result: Did not change the insulin and glucose concentrations in plasma.
Animal Model: ob/ob mouse model[2]
Dosage: 75 or 150 mg/kg
Administration: 75 or 150 mg/kg, per day, for 4 weeks
Result: Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots.
Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose.
Animal Model: Gottingen minipigs[2]
Dosage: 50 mg/kg
Administration: 50 mg/kg, per day, for 13 weeks
Result: Eliminated the blood glucose excursion in Minipigs.
Molecular Weight

455.63

Formula

C21H33N3O4S2

CAS No.
SMILES

OC(CSC1=CN=C(S1)NC(N(C2CCCCC2)[[email protected]]3CC[[email protected]@H](CC3)OCCC)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Cadisegliatin
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