2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. Cadisegliatin

Cadisegliatin  (Synonyms: TTP-399)

Cat. No.: HY-147254 Purity: 99.10%
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Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Cadisegliatin Chemical Structure

Cadisegliatin Chemical Structure

CAS No. : 859525-02-3

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

Cadisegliatin Related Antibodies

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Description

Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes[1][2].

In Vitro

Cadisegliatin (TTP-399) increases glucose metabolism in rat hepatocytes, the EC50 values of lactate and glycogen in 15 nM glucose are 2.39 μM and 2.64 μM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cadisegliatin Related Antibodies
In Vivo

TTP399 (200 mg/kg, per os, p.o.) has no effect on plasma glucose and insulin in fasted rats[2].
TTP399 (75 or 150 mg/kg, per day, for 4 weeks) improves glucose homeostasis in ob/ob mouse model[2].
TTP399 (50 mg/kg, per day, for 13 weeks) is effective in reducing plasma glucose during an oral glucose tolerance test (OGTT) in minipigs model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nondiabetic fasted rats[2]
Dosage: 200 mg/kg
Administration: 200 mg/kg, per os (p.o.)
Result: Did not change the insulin and glucose concentrations in plasma.
Animal Model: ob/ob mouse model[2]
Dosage: 75 or 150 mg/kg
Administration: 75 or 150 mg/kg, per day, for 4 weeks
Result: Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots.
Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose.
Animal Model: Gottingen minipigs[2]
Dosage: 50 mg/kg
Administration: 50 mg/kg, per day, for 13 weeks
Result: Eliminated the blood glucose excursion in Minipigs.
Molecular Weight

455.63

Formula

C21H33N3O4S2
CAS No.
Appearance

Solid

Color

Off-white to pale purple

SMILES

OC(CSC1=CN=C(S1)NC(N(C2CCCCC2)[C@H]3CC[C@@H](CC3)OCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (274.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1948 mL 10.9738 mL 21.9476 mL
5 mM 0.4390 mL 2.1948 mL 4.3895 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1948 mL 10.9738 mL 21.9476 mL 54.8691 mL
5 mM 0.4390 mL 2.1948 mL 4.3895 mL 10.9738 mL
10 mM 0.2195 mL 1.0974 mL 2.1948 mL 5.4869 mL
15 mM 0.1463 mL 0.7316 mL 1.4632 mL 3.6579 mL
20 mM 0.1097 mL 0.5487 mL 1.0974 mL 2.7435 mL
25 mM 0.0878 mL 0.4390 mL 0.8779 mL 2.1948 mL
30 mM 0.0732 mL 0.3658 mL 0.7316 mL 1.8290 mL
40 mM 0.0549 mL 0.2743 mL 0.5487 mL 1.3717 mL
50 mM 0.0439 mL 0.2195 mL 0.4390 mL 1.0974 mL
60 mM 0.0366 mL 0.1829 mL 0.3658 mL 0.9145 mL
80 mM 0.0274 mL 0.1372 mL 0.2743 mL 0.6859 mL
100 mM 0.0219 mL 0.1097 mL 0.2195 mL 0.5487 mL
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Cadisegliatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cadisegliatin859525-02-3TTP-399TTP399TTP 399GlucokinaseHexokinase IVHexokinase Dantihyperglycaemicglucokinase (GK) liver-selectiveglucokinasetype 2 diabetesInhibitorinhibitorinhibit

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