1. Biochemical Assay Reagents

Cremophor EL 

Cat. No.: HY-Y1890
Handling Instructions

Cremophor EL is a polyethoxylated surfactant.

For research use only. We do not sell to patients.

Cremophor EL Chemical Structure

Cremophor EL Chemical Structure

CAS No. : 61791-12-6

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Cremophor EL is a polyethoxylated surfactant.

In Vitro

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1].

References
Cell Assay
[1]

Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
CAS No.

61791-12-6

SMILES

[Cremophor EL]

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cremophor EL
Cat. No.:
HY-Y1890
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Cremophor EL

Cat. No.: HY-Y1890