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  4. Cremophor EL

Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents.

For research use only. We do not sell to patients.

Cremophor EL Chemical Structure

Cremophor EL Chemical Structure

CAS No. : 61791-12-6

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Based on 9 publication(s) in Google Scholar

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Cremophor EL Related Antibodies

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Description

Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents[1].

In Vitro

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cremophor EL Related Antibodies
CAS No.
Appearance

Liquid

SMILES

[Cremophor EL]
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Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (Need ultrasonic)

H2O : 25 mg/mL (Need ultrasonic)

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.52%

COA (241 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Cremophor EL Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cremophor EL61791-12-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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