Cremophor EL-40
Based on 23 publication(s) in Google Scholar
Cremophor EL-40, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL-40 is widely employed to improve dissolution and delivery of agents.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 61791-12-6
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cremophor EL-40
More- Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]
- Mil Med Res. 2022 Jul 6;9(1):37. [Abstract]
- Nat Metab. 2022 Sep;4(9):1166-1184. [Abstract]
- Sci Immunol. 2025 Jun 27;10(108):eadn1630. [Abstract]
- Neuron. 2026 Feb 18;114(4):759-773.e5. [Abstract]
- Autophagy. 2022 Aug;18(8):1879-1897. [Abstract]
- Adv Sci (Weinh). 2025 Sep 12:e09588. [Abstract]
- Int J Oral Sci. 2024 Jun 18;16(1):46. [Abstract]
- Cell Rep Med. 2024 Jul 16;5(7):101645. [Abstract]
- Acta Pharmacol Sin. 2024 Oct;45(10):2061-2076. [Abstract]
- Am J Obstet Gynecol. 2024 Jul;231(1):113.e1-113.e13. [Abstract]
- BMC Med. 2024 Feb 5;22(1):57. [Abstract]
- Cell Chem Biol. 2026 Apr 16;33(4):461-473.e7. [Abstract]
- Phytother Res. 2025 Aug;39(8):3526-3544. [Abstract]
- J Taiwan Inst Chem Eng. 2023 Feb.
- Chin Med. 2026 Jan 28;21(1):56. [Abstract]
- Mol Neurobiol. 2024 Oct;61(10):8438-8453. [Abstract]
- iScience. 2021 Sep 25;24(10):103170. [Abstract]
- ACS Chem Neurosci. 2025 Oct 1;16(19):3745-3757. [Abstract]
- BMC Cancer. 2022 Jul 9;22(1):749. [Abstract]
- Pain Res Manag. 2026;2026(1):e3334432. [Abstract]
- bioRxiv. 2026 Feb 26.
- University of Oklahoma. 2025.
Biological Activity
Cremophor EL-40 is a widely used excipient. In the first 10 h, Cremophor EL-40 at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL-40 decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL-40 at 24-h treatment. Cremophor EL-40 also enhances cell detachment[1].
Note:
Due to the nature of the product, it may solidify after being stored at 4°C. It can be heated in a 37°C water bath before use. It can be used normally after it is completely dissolved.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61791-12-6
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Appearance Liquid (Density: 1.05 g/mL)
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Color Light yellow to brown
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SMILES
[Cremophor EL-40]
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Synonyms
Polyoxyethylene(40) Castor Oil; PEG-40 Castor Oil
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (23)
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Journal Impact Factor
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Most Recent
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Mol Cancer
Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. [Abstract]2025 Mar 26;24(1):97. PMID: 40140842 -
Mil Med Res
Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury. [Abstract]2022 Jul 6;9(1):37. PMID: 35791006 -
Nat Metab
2022 Sep;4(9):1166-1184. PMID: 36123394 -
Sci Immunol
Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels. [Abstract]2025 Jun 27;10(108):eadn1630. PMID: 40577443 -
Neuron
2026 Feb 18;114(4):759-773.e5. PMID: 41638201 -
Autophagy
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma. [Abstract]2022 Aug;18(8):1879-1897. PMID: 34890308 -
Adv Sci (Weinh)
XBP1s Mediates Cross-resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer. [Abstract]2025 Sep 12:e09588. PMID: 40940685 -
Int J Oral Sci
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma. [Abstract]2024 Jun 18;16(1):46. PMID: 38886342 -
Cell Rep Med
Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling. [Abstract]2024 Jul 16;5(7):101645. PMID: 39019012 -
Acta Pharmacol Sin
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice. [Abstract]2024 Oct;45(10):2061-2076. PMID: 38789495 -
Am J Obstet Gynecol
Meclizine Improves Endometrial Repair and Reduces Simulated Menstrual Bleeding in Mice with Induced Adenomyosis. [Abstract]2024 Jul;231(1):113.e1-113.e13. PMID: 38367751 -
BMC Med
Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth. [Abstract]2024 Feb 5;22(1):57. PMID: 38317232 -
Cell Chem Biol
Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression. [Abstract]2026 Apr 16;33(4):461-473.e7. PMID: 41950925 -
Phytother Res
Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K/AKT Pathway. [Abstract]2025 Aug;39(8):3526-3544. PMID: 40616331 -
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Chin Med
Electroacupuncture ameliorates ulcerative colitis by suppressing ferroptosis via the JAK2/STAT3 signaling pathway. [Abstract]2026 Jan 28;21(1):56. PMID: 41606666 -
Mol Neurobiol
AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment. [Abstract]2024 Oct;61(10):8438-8453. PMID: 38512439 -
iScience
2021 Sep 25;24(10):103170. PMID: 34646996 -
ACS Chem Neurosci
Monitoring of Cerebral ROS and Alleviating Depressive-like Phenotype with a Curcumin-Derived Theranostic Probe. [Abstract]2025 Oct 1;16(19):3745-3757. PMID: 40952025 -
BMC Cancer
Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3. [Abstract]2022 Jul 9;22(1):749. PMID: 35810308 -
Pain Res Manag
SU-Eohyeol Pharmacopuncture Ameliorates Parkinson's Disease-Associated Pain via the CB1 and PPARγ Pathways in an MPTP-Induced Mouse Model. [Abstract]2026;2026(1):e3334432. PMID: 42218674 -
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Solvent & Solubility
H2O : 133.33 mg/mL (Need ultrasonic)
Ethanol : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: 5 mg/mL; Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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