1. Biochemical Assay Reagents
  2. Cremophor EL

Cremophor EL 

Cat. No.: HY-Y1890
Handling Instructions

Cremophor EL is a polyethoxylated surfactant.

For research use only. We do not sell to patients.

Cremophor EL Chemical Structure

Cremophor EL Chemical Structure

CAS No. : 61791-12-6

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Cremophor EL is a polyethoxylated surfactant.

In Vitro

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1].


4°C, protect from light

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (Need ultrasonic)

Cell Assay

Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.




[Cremophor EL]


Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cremophor EL
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Cremophor EL

Cat. No.: HY-Y1890