Cremophor EL-90
Cremophor EL-90 is a P-glycoprotein inhibitor that blocks P-glycoprotein-mediated efflux. Cremophor EL-90 solubilizes, protects, and encapsulates lipophilic bioactive compounds. Cremophor EL-90 enhances drug permeability and bioavailability when incorporated into SNEDDS. Cremophor EL-90 can be used in research on colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 61791-12-6
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
Cremophor EL-90 (at a 1:1 ratio with Capryol 90; 2 h) forms a clear emulsion with Capryol 90 and is selected for its high emulsification efficiency[1].
Cremophor EL-90 (Smix ratio 1:3-1:5; oil-to-Smix ratio 1:9-9:1) supports a broad self-nanoemulsifying region in the Capryol 90/PEG-400 system, thereby enabling determination of the SNEDDS composition range[1].
CO-IR-CP-SNs containing Cremophor EL-90 show a 1% hemolysis rate and have no hemolytic effect on red blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61791-12-6
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SMILES
[Cremophor EL-90]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)