CD85i/LIR-6

null CD85i, also called LIR-6 and LILRA2, is an activating member of the leukocyte immunoglobulin-like receptor family found on monocytes, macrophages and granulocytes. Its two extracellular immunoglobulin-like domains recognize immunoglobulin-superfamily proteins produced by certain microbes as well as host HLA ligands, and activating signals are delivered through associated Fc receptor gamma chains because the cytoplasmic tail lacks motifs of its own. LILRA2 contributes to antimicrobial defense, with genetic variation linked to altered susceptibility to mycobacterial disease. The receptor participates in the activating-to-inhibitory balance of the LILR system on myeloid cells.