CD85a/ILT-5
CD85a, better known as immunoglobulin-like transcript 5 (ILT-5, LILRB3), is an inhibitory receptor of the leukocyte immunoglobulin-like receptor family expressed on monocytes, macrophages, granulocytes and dendritic cells. Its extracellular region contains four immunoglobulin-like domains, while cytoplasmic immunoreceptor tyrosine-based inhibitory motifs recruit SHP-1 and SHP-2 phosphatases to dampen activation triggered by Fc receptors and Toll-like receptors. Ligand recognition includes HLA class I molecules and certain sialylated or microbial carbohydrate structures. CD85a is studied for its role in myeloid tolerance, antifungal immunity and as a candidate checkpoint in myeloid leukemia.
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CD85a/ILT-5 Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
