2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Immunodeficiency Disease

Immunodeficiency Disease

Immunodeficiency disorders predispose individuals to infections due to defects in immune system components, including lymphocytes, granulocytes, monocytes, antibodies, or complement proteins, resulting from genetic abnormalities (primary) or acquired conditions (secondary). The hallmark of these disorders is increased susceptibility to infections characterized by recurrent episodes, severe or prolonged courses, unusual pathogens, or atypical manifestations. B-cell deficiencies primarily lead to recurrent infections with encapsulated bacteria, while T-cell deficiencies are associated with recurrent viral, fungal, or protozoal infections. Phagocytic cell defects result in recurrent bacterial infections due to impaired pathogen engulfment and destruction, and complement deficiencies disrupt the activation of classical, alternative, or lectin pathways, compromising innate and adaptive immune defenses.

 

Immunodeficiency Disease (9):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-16767
    Doravirine 1338225-97-0 99.79%
    Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively.
    Doravirine
  • HY-104012
    Islatravir 865363-93-5 99.67%
    Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Islatravir
  • HY-164201
    HIV-1 inhibitor-69 257891-65-9 99.39%
    HIV-1 inhibitor-69 is an HIV-1 reverse transcriptase inhibitor. HIV-1 inhibitor-69 protects cells against HIV-1 infection. HIV-1 inhibitor-69 can be used for the research of acquired immunodeficiency syndrome (AIDS).
    HIV-1 inhibitor-69
  • HY-182506
    Azimexon 64118-86-1
    Azimexon (BM 12.531) is an orally active immunomodulator with radioprotective and antitumor activities. Azimexon prolongs survival in multiple mouse models, enhances immunity and hematopoiesis, and alleviates radiation injury and tumor metastasis. Azimexon causes reversible hemolytic anemia in rats and dogs, and exerts therapeutic activity against adjuvant-induced arthritis in rats. Azimexon can be used for the research of lung carcinoma, leukemia, multiple myeloma, lung tumor, arthritis, breast cancer and AIDS‑related complex.
    Azimexon
  • HY-181239
    PTP1B-IN-33 77500-30-2
    PTP1B-IN-33 is a PTP1B inhibitor with a human IC50 of 2.45 μM and over 20-fold selectivity for PTP1B over SHP2. PTP1B-IN-33 enhances π-Alkyl interaction with PTP1B to increase WPD loop closure degree. PTP1B-IN-33 can be used for the research of cancer, diabetes, autoimmune deficiency diseases.
    PTP1B-IN-33
  • HY-105097
    Atevirdine mesylate 138540-32-6
    Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS.
    Atevirdine mesylate
  • HY-180417
    U 88204 136816-76-7
    U 88204 is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC50 of 0.25 μM. U 88204 blocks HIV-1 replication in infected cells. U 88204 can be used for the research on HIV-infection and of acquired immunodeficiency syndrome (AIDs).
    U 88204
  • HY-180567
    PAC-Phe-Val 3088543-72-7
    PAC-Phe-Val is a potent HIV-1 protease inhibitor with an IC50 value of 33.10 nM. PAC-Phe-Val forms stable and strong interactions with critical active site residues, contributing to its high inhibitory potency. PAC-Phe-Val can be used for HIV/AIDS research.
    PAC-Phe-Val
  • HY-104012R
    Islatravir (Standard) 865363-93-5
    Islatravir (Standard) is the analytical standard of Islatravir (HY-104012). This product is intended for research and analytical applications. Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Islatravir (Standard)