129388-64-3
Chemical Structure
Kijimicin sodium
- CAS No.: 129388-64-3
- Formula:C37H63NaO11
- Molecular Weight:706.88
InChIKey: PUTZNLVFKVOXJY-KGEQOXMGSA-M
SMILES: C[C@H](C([C@H](C)[C@@H](OC)[C@H]1C)O[C@]21CC[C@@H]([C@H]3CC[C@@](O3)([C@@H]4O[C@@H]([C@@]5(O)O[C@](C[C@@H]5C)(C)[C@H](O)CC)C[C@@H]4C)C)O2)[C@@H](OC)[C@H](C)C(O[Na])=O
Biological Activity: Kijimicin sodium is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. Kijimicin sodium inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin sodium exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin sodium can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections[1][2][3][4].
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Kijimicin sodium | Kijimicin sodium is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. Kijimicin sodium inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin sodium exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin sodium can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections. | |||||||||||||||||||||
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- [1]. Yamauchi T, et al. Mechanistic effects of kijimicin on inhibition of human immunodeficiency virus replication. Mol Cell Biochem. 1993 Feb 17;119(1-2):35-41. [Content Brief]
- [2]. Takahashi Y, et al. Kijimicin, a polyether antibiotic. J Antibiot (Tokyo). 1990 Apr;43(4):441-3. [Content Brief]
- [3]. Kubota R, et al. Development of a Luciferase-Based In Vitro Assay to Evaluate the Efficacy of Anti-Cryptosporidial Drugs Against Cryptosporidium parvum. Pharmaceuticals (Basel). 2026 Apr 3;19(4):576. [Content Brief]
- [4]. Leesombun, et al. Efficacy of piperaceae plant extracts and microorganism-derived compounds: metacytofilin and kijimicin against Toxoplasma gondii, 帯広畜産大学, 2017-09-29.
Keywords
