1. Signaling Pathways
  2. Epigenetics
  3. Protein Arginine Deiminase

Protein Arginine Deiminase

Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Protein Arginine Deiminase Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-100514
    GSK484 hydrochloride Inhibitor 98.00%
    GSK484 hydrochloride (GTPL8577) is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride (GTPL8577) demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.
  • HY-111347A
    BB-Cl-Amidine hydrochloride Inhibitor 99.98%
    BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.
  • HY-100574A
    Cl-amidine hydrochloride Inhibitor
    Cl-amidine (hydrochloride) is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9 μM for PAD4.
  • HY-111347
    BB-Cl-Amidine Inhibitor
    BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.
  • HY-112903
    YW3-56 Inhibitor
    YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with IC50s of 0.5-1 μM and 1-2 μM for PAD2 and PAD4, respectively.
  • HY-124586
    Streptonigrin Inhibitor
    Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively.
  • HY-100574
    Cl-amidine Inhibitor
    Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9 μM for PAD4.
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