1. Epigenetics
  2. Protein Arginine Deiminase
  3. BB-Cl-Amidine hydrochloride

BB-Cl-Amidine hydrochloride 

Cat. No.: HY-111347A Purity: 99.98%
Handling Instructions

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.

For research use only. We do not sell to patients.

BB-Cl-Amidine hydrochloride Chemical Structure

BB-Cl-Amidine hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in Water USD 104 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 95 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Description

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.

IC50 & Target

PAD[1].

In Vivo

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].

Animal Model: MRL/lpr mice[1].
Dosage: 1 mg/kg.
Administration: Subcutaneous injection daily from 8 to 14 weeks of age.
Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

496.43

Formula

C₂₆H₂₇Cl₂N₅O

SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[[email protected]](C3=NC4=CC=CC=C4N3)CCCNC(CCl)=N.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BB-Cl-Amidine hydrochloride
Cat. No.:
HY-111347A
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BB-Cl-Amidine hydrochloride

Cat. No.: HY-111347A