1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Isoform Specific Products:

  • HSP40

  • HSP70

  • HSP90

  • HSP105

  • HSF1

  • HSP

HSP Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-10211
    17-AAG Inhibitor 99.03%
    17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
  • HY-15205
    Ganetespib Inhibitor 99.56%
    Ganetespib is a unique non-geldanamycin heat shock protein 90 (HSP90) inhibitor, with antitumor activity.
  • HY-32735
    Triptolide Inhibitor 99.83%
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-15230
    Geldanamycin Inhibitor 99.78%
    Geldanamycin is a specific inhibitor of interferon regulatory factor 3 (IRF3) (by inhibiting Hsp90 of the IRF3 phosphorylation chaperone, with a Kd of 1.2 μM.).
  • HY-10215
    NVP-AUY922 Inhibitor 99.14%
    NVP-AUY922 is a potent HSP90 inhibitor with IC50s of 7.8 nM/21 nM for HSP90α/β, respectively, and has weaker potency against the HSP90 family members GRP94 and TRAP-1 (IC50, 535 nM, 85 nM, respectively).
  • HY-13313
    XL888 Inhibitor 99.24%
    XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC50 of 24 nM.
  • HY-10940
    Pifithrin-μ Inhibitor
    Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
  • HY-B1425
    Ethoxyquin Inhibitor 98.05%
    Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).
  • HY-19356
    Rocaglamide Inhibitor 99.40%
    Rocaglamide is potent and selective for heat shock reporter (IC50 of 50 nM) and for the control reporter (IC50>1000 nM).
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin hydrochloride is a novel and highly soluble inhibitor of the Hsp90 ATPase activity, with EC50s of 119 nM for both Hsp90 and Grp9.
  • HY-14463
    AT13387 Inhibitor 99.64%
    AT13387 is a potent inhibitor of Hsp90, with Kd of 0.71 nM.
  • HY-10941
    VER-155008 Inhibitor 99.64%
    VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
  • HY-B0779
    Teprenone Activator >98.0%
    Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
  • HY-10212
    BIIB021 Inhibitor 99.62%
    BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
  • HY-12024
    Alvespimycin hydrochloride Inhibitor 99.32%
    Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
  • HY-13469
    Debio 0932 Inhibitor 99.44%
    Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
  • HY-15098
    Apoptozole Inhibitor 99.57%
    Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
  • HY-15190
    NVP-HSP990 Inhibitor 98.59%
    NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.
  • HY-100872
    KRIBB11 Inhibitor 99.04%
    KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
  • HY-18680
    PU-WS13 Inhibitor
    PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
Isoform Specific Products

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