1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Related Products (27):

Cat. No. Product Name Effect Purity
  • HY-10211
    17-AAG Inhibitor
    17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
  • HY-10215
    NVP-AUY922 Inhibitor
    NVP-AUY922 is a highly potent HSP90 inhibitor with IC50 of 13 nM/21 nM for for HSP90α/β, respectively, and has weaker potency against the HSP90 family members GRP94 and TRAP-1.
  • HY-15205
    Ganetespib Inhibitor
    Ganetespib is a unique non-geldanamycin heat shock protein 90 (HSP90) inhibitor, with IC50 of 4 nM in OSA 8 cells.
  • HY-32735
    Triptolide Inhibitor
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-15230
    Geldanamycin Inhibitor
    Geldanamycin is a specific inhibitor of interferon regulatory factor 3 (IRF3) (by inhibiting Hsp90 of the IRF3 phosphorylation chaperone).
  • HY-12622
    HSP70-IN-1 Inhibitor
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
  • HY-100872
    KRIBB11 Inhibitor
    KRIBB11 is an inhibitor of Heat shock factor (HSF), with IC50 of 1.2 μM.
  • HY-15098
    Apoptozole Inhibitor
    Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity.
  • HY-19356
    Rocaglamide Inhibitor
    Rocaglamide is potent and selective for heat shock reporter (IC50 of 50 nM) and for the control reporter (IC50>1000 nM).
  • HY-B0779
    Teprenone Activator
    Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
  • HY-12024
    Alvespimycin hydrochloride Inhibitor
    Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin hydrochloride is a novel and highly soluble inhibitor of the Hsp90 ATPase activity.
  • HY-10212
    BIIB021 Inhibitor
    BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
  • HY-13469
    Debio 0932 Inhibitor
    Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).
  • HY-10941
    VER-155008 Inhibitor
    VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines.
  • HY-14463
    AT13387 Inhibitor
    AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.
  • HY-15190
    NVP-HSP990 Inhibitor
    NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity.
  • HY-10942
    NVP-BEP800 Inhibitor
    NVP-BEP800(VER82576) is a novel, fully synthetic, oral Hsp90 inhibitor with an IC50 of 0.058 ± 0.006 μM.
  • HY-18680
    PU-WS13 Inhibitor
    PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class.
  • HY-100110
    KNK437 Inhibitor
    KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells. It also inhibit mRNA levels with IC 50: 17 umol/L.