1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Isoform Specific Products:

  • HSP40

  • HSP70

  • HSP90

  • HSP105

  • HSF1

  • HSP

HSP Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-10211
    Tanespimycin Inhibitor 99.03%
    17-AAG is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90.
  • HY-15205
    Ganetespib Inhibitor 99.56%
    Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.
  • HY-10215
    Luminespib Inhibitor 99.14%
    NVP-AUY922 is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively.
  • HY-15230
    Geldanamycin Inhibitor 99.78%
    Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
  • HY-14463
    AT13387 Inhibitor 99.64%
    AT13387 (Onalespib) is a potent inhibitor of Hsp90, with a Kd of 0.71 nM.
  • HY-108248
    KU-32 Inhibitor
    KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.
  • HY-13468
    KW-2478 Inhibitor >98.0%
    KW-2478 is an inhibitor of Hsp90α, with an IC50 of 3.8 nM, and has antitumor activity against various human hematological tumor cells.
  • HY-106443A
    Arimoclomol maleate Activator
    Arimoclomol maleate is a co-inducer of heat shock proteins (HSP).
  • HY-10941
    VER-155008 Inhibitor 99.64%
    VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
  • HY-12024
    Alvespimycin hydrochloride Inhibitor 99.32%
    Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
  • HY-10212
    BIIB021 Inhibitor 99.93%
    BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
  • HY-100872
    KRIBB11 Inhibitor 99.04%
    KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
  • HY-B0779
    Teprenone Activator >98.0%
    Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin Hydrochloride is a potent and water-soluble inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
  • HY-15098
    Apoptozole Inhibitor 99.57%
    Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
  • HY-13469
    Debio 0932 Inhibitor 99.44%
    Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
  • HY-100110
    KNK437 Inhibitor >98.0%
    KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.
  • HY-18680
    PU-WS13 Inhibitor
    PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
  • HY-15190
    NVP-HSP990 Inhibitor 98.98%
    NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.
  • HY-103000
    HSF1A Activator 99.33%
    HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1).
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.