1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
    Autophagy
  2. HSP
    Autophagy

VER-155008 

Cat. No.: HY-10941 Purity: 98.83%
Data Sheet SDS Handling Instructions

VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines.

For research use only. We do not sell to patients.
VER-155008 Chemical Structure

VER-155008 Chemical Structure

CAS No. : 1134156-31-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
5 mg USD 72 In-stock
10 mg USD 96 In-stock
50 mg USD 336 In-stock
100 mg USD 540 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines. IC50 value: 5.3-14.4 uM(GI50); 80 nM(Kd) [1] [2] Target: Hsp70 inhibitor in vitro: VER-155008 inhibited the proliferation of human breast and colon cancer cell lines with GI(50)s in the range 5.3-14.4 microM, and induced Hsp90 client protein degradation in both HCT116 and BT474 cells. As a single agent, VER-155008 induced caspase-3/7 dependent apoptosis in BT474 cells and non-caspase dependent cell death in HCT116 cells. VER-155008 potentiated the apoptotic potential of a small molecule Hsp90 inhibitor in HCT116 but not HT29 or MDA-MB-468 cells [1]. VER-155008 (HCT116 GI50 = 5 μM), has similar potencies in both Grp78 and Hsp70 [2]. Inhibition of Hsp70/Hsc70 activity with VER 155008 attenuated the protection afforded by N-acetyl cysteine in a dose-responsive manner [3]. in vivo: VER-155008 demonstrated rapid metabolism and clearance, along with tumor levels below the predicted pharmacologically active level [1].

References
Molecular Weight

556.4

Formula

C₂₅H₂₃Cl₂N₇O₄

CAS No.

1134156-31-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 37 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.83%

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Product Name:
VER-155008
Cat. No.:
HY-10941
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